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Literature summary extracted from

  • Kosa, N.M.; Foley, T.L.; Burkart, M.D.
    Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors (2014), J. Antibiot., 67, 113-120.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.7 gene AASDHPPT, recombinant expression of the Sfp-PPTase from plasmid pET29b in Escherichia coli strain BL21(DE3) Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.7 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.7 CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] Homo sapiens
-
 adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.7 Homo sapiens Q9NRN7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.7 CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
 Homo sapiens adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 additional information development of a direct and continuous assay for this enzyme class based upon monitoring polarization of a fluorescent phosphopantetheine analogue as it is transferred from a low molecular weight coenzyme A substrate to higher molecular weight protein acceptor, utility of the method for the biochemical characterization of phosphopantetheinyl transferase Sfp, a canonical enzyme, recombinant enzyme with substrates VibB and 90 amino acid ACP (hACP) from human fatty acid synthase, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.7 AASDHPPT
-
 Homo sapiens
2.7.8.7 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase UniProt Homo sapiens
2.7.8.7 phosphopantetheinyl transferase
-
 Homo sapiens
2.7.8.7 PPTase
-
 Homo sapiens
2.7.8.7 Sfp
-
 Homo sapiens
2.7.8.7 Sfp-PPTase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.7 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.7 6.7
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.8.7 physiological function phosphopantetheinyl transferase activates biosynthetic pathways that synthesize both primary and secondary metabolites in bacteria Homo sapiens