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Literature summary extracted from

  • Kamigiri, K.; Hidaka, T.; Imai, S.; Murakami, T.; Seto, H.
    Studies on the biosynthesis of bialaphos (SF-1293) 12. C-P bond formation mechanism of bialaphos: discovery of a P-methylation enzyme (1992), J. Antibiot., 45, 781-787.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.326 expression in Streptomyces lividans Streptomyces hygroscopicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.326 Streptomyces hygroscopicus
-
-
-
2.1.1.326 Streptomyces hygroscopicus SF-1293
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.326 2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor
-
 Streptomyces hygroscopicus S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor
-
 ?
2.1.1.326 2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor
-
 Streptomyces hygroscopicus SF-1293 S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor
-
 ?
2.1.1.326 S-adenosyl-L-methionine + N-acetyldemethylbialaphos + reduced acceptor
-
 Streptomyces hygroscopicus ?
-
 ?
2.1.1.326 S-adenosyl-L-methionine + N-acetyldemethylbialaphos + reduced acceptor
-
 Streptomyces hygroscopicus SF-1293 ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.326 methylcob(III)alamin methyl donor of the reaction Streptomyces hygroscopicus

General Information

EC Number General Information Comment Organism
2.1.1.326 physiological function the bacterial enzyme produces the tripeptides bialaphos and phosalacine, which inhibit plant and bacterial glutamine synthetase Streptomyces hygroscopicus