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Literature summary extracted from

  • Blanco, B.; Prado, V.; Lence, E.; Otero, J.M.; Garcia-Doval, C.; van Raaij, M.J.; Llamas-Saiz, A.L.; Lamb, H.; Hawkins, A.R.; Gonzalez-Bello, C.
    Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover (2013), J. Am. Chem. Soc., 135, 12366-12376.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.71 in complex with ADP and inhibitor, sitting drop vapor diffusion method, using 20% (w/v) poly(ethyleneglycol) 3350, 0.5 M LiCl, and 100 mM Tris-HCl pH 7.8 Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.71 (+)-4-epi-shikimic acid
-
 Mycobacterium tuberculosis
2.7.1.71 (+)-pinitol
-
 Mycobacterium tuberculosis
2.7.1.71 (-)-4-epi-shikimic acid
-
 Mycobacterium tuberculosis
2.7.1.71 (-)-pinitol
-
 Mycobacterium tuberculosis
2.7.1.71 L-Tartaric acid
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.71 ATP + shikimate Mycobacterium tuberculosis
-
 ADP + 3-phosphoshikimate
-
 ?
2.7.1.71 ATP + shikimate Mycobacterium tuberculosis H37Rv
-
 ADP + 3-phosphoshikimate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.71 Mycobacterium tuberculosis P9WPY3
-
-
2.7.1.71 Mycobacterium tuberculosis H37Rv P9WPY3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.71 ATP + shikimate
-
 Mycobacterium tuberculosis ADP + 3-phosphoshikimate
-
 ?
2.7.1.71 ATP + shikimate
-
 Mycobacterium tuberculosis H37Rv ADP + 3-phosphoshikimate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.71 AroK
-
 Mycobacterium tuberculosis