Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dickinson, A.; Meyer, M.; Pawlak, E.; Gomez, S.; Jaspers, I.; Allbritton, N.
    Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood (2015), Integr. Biol., 7, 392-401.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.91 ATP + sphingosine Homo sapiens
-
ADP + sphingosine 1-phosphate
-
?
2.7.1.91 additional information Homo sapiens the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens Q9NRA0 isozyme SPHK2; gene SphK2
-
2.7.1.91 Homo sapiens Q9NYA1 isozyme SPHK1; gene SphK1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 natural killer cell the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
2.7.1.91 additional information the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound Homo sapiens ?
-
?
2.7.1.91 additional information use of an automated single-cell capillary electrophoresis system to characterize the sphingosine-1-phosphate pathway in single primary human NK cells from peripheral blood, method development, overview. The automated single-cell CE system increases throughput 100fold compared to that attained by non-automated systems, permitting the analysis of sufficiently large sample sizes to identify statistically significant differences of sphingosine-1-phosphate pathway signaling Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 SPHK1
-
Homo sapiens
2.7.1.91 SPHK2
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.91 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.91 7.4
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.91 malfunction dysregulation of the sphingosine-1-phosphate pathway is linked to a number of immune system disorders Homo sapiens
2.7.1.91 physiological function sphingosine-1-phosphate is a lipid second messenger formed upon phosphorylation of sphingosine by sphingosine kinase and plays a crucial role in natural killer cell proliferation, migration, and cytotoxicity Homo sapiens