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Literature summary extracted from

  • Fereidoonnezhad, M.; Faghih, Z.; Mojaddami, A.; Sakhteman, A.; Rezaei, Z.
    A comparative docking studies of dichloroacetate analogues on four isozymes of pyruvate dehydrogenase kinase in humans (2016), Indian J. Pharm. Edu. Res., 50, S32-S38.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.2 Dichloroacetate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (acetyl-transferring)] Homo sapiens
-
 ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Homo sapiens Q15118
-
-
2.7.11.2 Homo sapiens Q15119
-
-
2.7.11.2 Homo sapiens Q15120
-
-
2.7.11.2 Homo sapiens Q16654
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (acetyl-transferring)]
-
 Homo sapiens ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.2 PDK1 isoform Homo sapiens
2.7.11.2 PDK2 isoform Homo sapiens
2.7.11.2 PDK3 isoform Homo sapiens
2.7.11.2 PDK4 isoform Homo sapiens
2.7.11.2 pyruvate dehydrogenase kinase
-
 Homo sapiens