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Literature summary extracted from

  • Belda-Palazon, B.; Almendariz, C.; Marti, E.; Carbonell, J.; Ferrando, A.
    Relevance of the axis spermidine/eIF5A for plant growth and development (2016), Front. Plant Sci., 7, 245.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.46 additional information generation of deoxyhypusine synthase knockout mutants using siRNA via Agrobacterium strainGV3101/pMP90 transfection in Arabidopsis thaliana Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Arabidopsis thaliana
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Arabidopsis thaliana Col-0
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Arabidopsis thaliana Q9FI94 gene dhs
-
2.5.1.46 Arabidopsis thaliana Col-0 Q9FI94 gene dhs
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Arabidopsis thaliana [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine transfer of a 4-aminobutyl moiety group Arabidopsis thaliana [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Arabidopsis thaliana Col-0 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine transfer of a 4-aminobutyl moiety group Arabidopsis thaliana Col-0 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

General Information

EC Number General Information Comment Organism
2.5.1.46 malfunction early flowering phenotype of dexamethasone-treated siDHS knockout transgenic plants, hypersensitivityof siDHS transgenic plants to osmotic stressors and abscisic acid. The sensitivity of transgenic siDHS plantsto abscisic acid in the absence of the silencing drug dexamethasone probably reflects that the genetic inactivation system is slightly leaky and that minor inactivation of the eIF5A pathway is very sensitive to alterations in abscisic acid homeostasis. Non-silenced siDHS plants display partial growth inhibition under salt treatment. Alterations in root cell expansion and root hair phenotypes caused by DHS silencing, overview Arabidopsis thaliana
2.5.1.46 physiological function the enzyme is required for spermidine-mediated activation of eIF5A by hypusination. Activated elF5A is involved in several aspects of plant biology such as the control of flowering time, the aerial and root architecture, and root hair growth. In addition, the pathway is required for adaptation to challenging growth conditions such as high salt and high glucose medium and to elevated concentrations of the plant hormone abscisic acid Arabidopsis thaliana