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Literature summary extracted from

  • Rizner, T.L.
    The important roles of steroid sulfatase and sulfotransferases in gynecological diseases (2016), Front. Pharmacol., 7, 30.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.2 0.0023
-
 dehydroepiandrosterone isoform SULT2B1a, pH and temperature not specified in the publication Homo sapiens
2.8.2.2 0.0025
-
 dehydroepiandrosterone isoform SULT2A1, pH and temperature not specified in the publication Homo sapiens
2.8.2.2 0.0044
-
 dehydroepiandrosterone isoform SULT2B1b, pH and temperature not specified in the publication Homo sapiens
2.8.2.4 0.00011
-
 estrone pH and temperature not specified in the publication Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.2 34000
-
 x * 34000, SDS-PAGE Homo sapiens
2.8.2.4 35000
-
 x * 35000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone Homo sapiens
-
 adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + pregnenolone Homo sapiens
-
 adenosine 3',5'-bisphosphate + pregnenolone sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens O00204
-
-
2.8.2.4 Homo sapiens P49888
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 brain fetal brain Homo sapiens
-
2.8.2.2 colon
-
 Homo sapiens
-
2.8.2.2 liver
-
 Homo sapiens
-
2.8.2.2 ovary
-
 Homo sapiens
-
2.8.2.2 placenta
-
 Homo sapiens
-
2.8.2.2 prostate gland
-
 Homo sapiens
-
2.8.2.2 small intestine
-
 Homo sapiens
-
2.8.2.2 uterine endometrium
-
 Homo sapiens
-
2.8.2.2 uterus
-
 Homo sapiens
-
2.8.2.4 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone
-
 Homo sapiens adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + pregnenolone
-
 Homo sapiens adenosine 3',5'-bisphosphate + pregnenolone sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.2 ? x * 34000, SDS-PAGE Homo sapiens
2.8.2.4 ? x * 35000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 SULT2B1
-
 Homo sapiens
2.8.2.4 SULT1E1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.2.2 Homo sapiens the expression of SULT2B1 at the mRNA level is decreased in ovarian endometriosis compared to normal endometrium down
2.8.2.2 Homo sapiens the enzyme expression is upregulated in endometrial cancer up
2.8.2.4 Homo sapiens the enzyme expression is downregulated in ovarian cancer up
2.8.2.4 Homo sapiens there are significantly higher mRNA levels in ectopic endometrium of deep infiltrating endometriosis, when compared to the normal endometrium. The enzyme expression is upregulated in endometrial cancer up