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Literature summary extracted from

  • Hung, C.; Kobayashi, K.; Wada, H.; Nakamura, Y.
    Functional specificity of cardiolipin synthase revealed by the identification of a cardiolipin synthase CrCLS1 in Chlamydomonas reinhardtii (2016), Front. Microbiol., 6, 1542.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.41 gene CrCLS1, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative RT-PCR expression analysis, the gene cannot perform functional complementation of pgsA, a PGPS mutant of Synechocystis sp. PCC6803, but of DELTAcrd1, a CLS mutant of Saccharomyces cerevisiae Chlamydomonas reinhardtii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.41 mitochondrial membrane
-
 Chlamydomonas reinhardtii 31966
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.41 Mn2+ required Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Chlamydomonas reinhardtii
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Chlamydomonas reinhardtii CC-503
-
 a cardiolipin + CMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.41 Chlamydomonas reinhardtii A8JAW5 cw92mt+
-
2.7.8.41 Chlamydomonas reinhardtii CC-503 A8JAW5 cw92mt+
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Chlamydomonas reinhardtii a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Chlamydomonas reinhardtii CC-503 a cardiolipin + CMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.41 cardiolipin synthase
-
 Chlamydomonas reinhardtii
2.7.8.41 CHLREDRAFT_177689
-
 Chlamydomonas reinhardtii
2.7.8.41 CLS
-
 Chlamydomonas reinhardtii
2.7.8.41 CrCLS1
-
 Chlamydomonas reinhardtii
2.7.8.41 Cre13.g604700 locus name Chlamydomonas reinhardtii
2.7.8.41 phosphatidylglycerophosphate synthase-like protein UniProt Chlamydomonas reinhardtii

General Information

EC Number General Information Comment Organism
2.7.8.41 evolution phosphatidylglycerophosphate synthase (PGPS) and cardiolipin synthase (CLS) are both involved in the biosynthesis of phosphatidylglycerol and cardiolipin and belong to the CDP-alcohol phosphotransferases, they share overall amino acid sequence homology. PGPS and CLS are functionally distinct in vivo. Comparison of CDP-alcohol phosphotransferase motifs between PGPS and CLS among different species reveal a possible additional motif that might define the substrate specificity of the closely related enzymes Chlamydomonas reinhardtii
2.7.8.41 metabolism cardiolipin synthase is involved in the biosynthesis of cardiolipin Chlamydomonas reinhardtii
2.7.8.41 physiological function gene CrCLS1 does not complement the growth phenotype of a phosphatidylglycerophosphate synthase (PGPS) mutant of Synechocystis sp. PCC6803, but it rescues the temperature-sensitive growth phenotype, growth profile with different carbon sources, phospholipid composition, and enzyme activity of DELTAcrd1, a cardiolipin synthase (CLS) mutant of Saccharomyces cerevisiae Chlamydomonas reinhardtii