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Literature summary extracted from

  • Porciello, N.; Kunkl, M.; Viola, A.; Tuosto, L.
    Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation (2016), Front. Immunol., 7, 186.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.68 phosphatidic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.68 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 T-cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.68 phosphatidylinositol 4,5-biphosphate kinase
-
 Homo sapiens
2.7.1.68 PIP5Kalpha isoform Homo sapiens
2.7.1.68 PIP5Kbeta isoform Homo sapiens
2.7.1.68 PIP5Kgamma isoform Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.68 physiological function T lymphocyte triggering is finely tuned by phosphatidylinositol 4,5-biphosphate kinases activity Homo sapiens