show Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase
Yamanishi, M.; Narazaki, H.; Asano, T.; Exp. Hematol. 43, 207-214 (2015)
Data extracted from this reference:
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
NTP + deoxycytidine
Homo sapiens
-
NDP + dCMP
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
NALM-6 cell
-
Homo sapiens
-
2.7.1.74
SKW-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
NTP + clofarabine
-
738175
Homo sapiens
NDP + clofarabine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
738175
Homo sapiens
NDP + dCMP
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
NTP + deoxycytidine
Homo sapiens
-
NDP + dCMP
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
NALM-6 cell
-
Homo sapiens
-
2.7.1.74
SKW-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
NTP + clofarabine
-
738175
Homo sapiens
NDP + clofarabine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
738175
Homo sapiens
NDP + dCMP
-
-
-
?