EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | additional information | no inhibition of activity of isozyme DAGKepsilon with 1-stearoyl-2-arachidonoylglycerol by R59022, a type I DAGK inhibitor | Bos taurus | |
2.7.1.107 | additional information | no inhibition by R59022, a type I DAGK inhibitor | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.107 | photoreceptor outer segment | from albino rats, isozyme DAGKepsilon appears to be higher in rod outer segments from rat retinas exposed to light than in those under dark conditions. DAGKepsilon in rat retina naturally exposed to room light is present in all retinal layers and is distributed along the photoreceptor cell | Rattus norvegicus | 1750 | - |
2.7.1.107 | photoreceptor outer segment | in bovine rod outer segments obtained from retinas under room light conditions, DAGKepsilon and type I DAGK activity is present. Isozyme DAGKepsilon appears to be higher in rod outer segments from bleached bovine retinas than in those under dark conditions | Bos taurus | 1750 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | Mg2+ | required | Rattus norvegicus | |
2.7.1.107 | Mg2+ | required | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | Rattus norvegicus | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | Bos taurus | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | Rattus norvegicus Wistar | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.107 | Bos taurus | - |
- |
- |
2.7.1.107 | Rattus norvegicus | - |
- |
- |
2.7.1.107 | Rattus norvegicus Wistar | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.107 | additional information | light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light | Rattus norvegicus | - |
2.7.1.107 | additional information | light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light | Bos taurus | - |
2.7.1.107 | photoreceptor cell | the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell | Rattus norvegicus | - |
2.7.1.107 | photoreceptor cell | the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell | Bos taurus | - |
2.7.1.107 | retina | - |
Rattus norvegicus | - |
2.7.1.107 | retina | - |
Bos taurus | - |
2.7.1.107 | retinal rod | from albino rats, isozyme DAGKepsilon appears to be higher in rod outer segments from rat retinas exposed to light than in those under dark conditions. DAGKepsilon in rat retina naturally exposed to room light is present in all retinal layers and is distributed along the photoreceptor cell | Rattus norvegicus | - |
2.7.1.107 | retinal rod | in bovine rod outer segments obtained from retinas under room light conditions, DAGKepsilon and type I DAGK activity is present. Isozyme DAGKepsilon appears to be higher in rod outer segments from bleached bovine retinas than in those under dark conditions | Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | - |
Rattus norvegicus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | - |
Bos taurus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol | - |
Rattus norvegicus Wistar | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
2.7.1.107 | ATP + 1,2-dioleoylglycerol | low activity | Bos taurus | ADP + 1,2-dioleoylglycerol 3-phospate | - |
? | |
2.7.1.107 | ATP + 1-stearoyl-2-arachidonoylglycerol | preferred enzyme, 6fold higher activity compared to substrate 1,2-dioleoylglycerol | Bos taurus | ADP + 1-stearoyl-2-arachidonoylglycerol 3-phosphate | - |
? | |
2.7.1.107 | additional information | enzyme assays with isolated rod outer segments prepared under room light from retinas obtained from dark-adapted bovine eyes | Bos taurus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.107 | 1,2-diacylglycerol kinase epsilon | - |
Rattus norvegicus |
2.7.1.107 | 1,2-diacylglycerol kinase epsilon | - |
Bos taurus |
2.7.1.107 | DAGK | - |
Rattus norvegicus |
2.7.1.107 | DAGK | - |
Bos taurus |
2.7.1.107 | DAGKepsilon | - |
Rattus norvegicus |
2.7.1.107 | DAGKepsilon | - |
Bos taurus |
2.7.1.107 | diacylglycerol kinase epsilon | - |
Rattus norvegicus |
2.7.1.107 | diacylglycerol kinase epsilon | - |
Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.107 | 37 | - |
assay at | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.107 | 7.4 | - |
assay at | Rattus norvegicus |
2.7.1.107 | 7.4 | - |
assay at | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | ATP | - |
Rattus norvegicus | |
2.7.1.107 | ATP | - |
Bos taurus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.107 | physiological function | the enzyme is involved in a mechanism of light-regulated DAGK activity in the photoreceptors of the vertebrate species. Protein kinase C-dependent phosphorylation of retina rod outer segments (obtained from bovine retinas at room light) regulates DAGK activity | Bos taurus |
2.7.1.107 | physiological function | the enzyme is involved in a mechanism of light-regulated DAGK activity in the photoreceptors of the vertebrate species. Protein kinase C-dependent phosphorylation of retina rod outer segments regulates DAGK activity | Rattus norvegicus |