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Literature summary extracted from

  • Natalini, P.M.; Zulian, S.E.; Ilincheta de Boschero, M.G.; Giusto, N.M.
    Diacylglycerol kinase epsilon in bovine and rat photoreceptor cells. Light-dependent distribution in photoreceptor cells (2013), Exp. Eye Res., 112, 139-150.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.107 additional information no inhibition of activity of isozyme DAGKepsilon with 1-stearoyl-2-arachidonoylglycerol by R59022, a type I DAGK inhibitor Bos taurus
2.7.1.107 additional information no inhibition by R59022, a type I DAGK inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 photoreceptor outer segment from albino rats, isozyme DAGKepsilon appears to be higher in rod outer segments from rat retinas exposed to light than in those under dark conditions. DAGKepsilon in rat retina naturally exposed to room light is present in all retinal layers and is distributed along the photoreceptor cell Rattus norvegicus 1750
-
2.7.1.107 photoreceptor outer segment in bovine rod outer segments obtained from retinas under room light conditions, DAGKepsilon and type I DAGK activity is present. Isozyme DAGKepsilon appears to be higher in rod outer segments from bleached bovine retinas than in those under dark conditions Bos taurus 1750
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.107 Mg2+ required Rattus norvegicus
2.7.1.107 Mg2+ required Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Rattus norvegicus
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Bos taurus
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Rattus norvegicus Wistar
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Bos taurus
-
-
-
2.7.1.107 Rattus norvegicus
-
-
-
2.7.1.107 Rattus norvegicus Wistar
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 additional information light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light Rattus norvegicus
-
2.7.1.107 additional information light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light Bos taurus
-
2.7.1.107 photoreceptor cell the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell Rattus norvegicus
-
2.7.1.107 photoreceptor cell the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell Bos taurus
-
2.7.1.107 retina
-
Rattus norvegicus
-
2.7.1.107 retina
-
Bos taurus
-
2.7.1.107 retinal rod from albino rats, isozyme DAGKepsilon appears to be higher in rod outer segments from rat retinas exposed to light than in those under dark conditions. DAGKepsilon in rat retina naturally exposed to room light is present in all retinal layers and is distributed along the photoreceptor cell Rattus norvegicus
-
2.7.1.107 retinal rod in bovine rod outer segments obtained from retinas under room light conditions, DAGKepsilon and type I DAGK activity is present. Isozyme DAGKepsilon appears to be higher in rod outer segments from bleached bovine retinas than in those under dark conditions Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
Rattus norvegicus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
Bos taurus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
Rattus norvegicus Wistar ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-dioleoylglycerol low activity Bos taurus ADP + 1,2-dioleoylglycerol 3-phospate
-
?
2.7.1.107 ATP + 1-stearoyl-2-arachidonoylglycerol preferred enzyme, 6fold higher activity compared to substrate 1,2-dioleoylglycerol Bos taurus ADP + 1-stearoyl-2-arachidonoylglycerol 3-phosphate
-
?
2.7.1.107 additional information enzyme assays with isolated rod outer segments prepared under room light from retinas obtained from dark-adapted bovine eyes Bos taurus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 1,2-diacylglycerol kinase epsilon
-
Rattus norvegicus
2.7.1.107 1,2-diacylglycerol kinase epsilon
-
Bos taurus
2.7.1.107 DAGK
-
Rattus norvegicus
2.7.1.107 DAGK
-
Bos taurus
2.7.1.107 DAGKepsilon
-
Rattus norvegicus
2.7.1.107 DAGKepsilon
-
Bos taurus
2.7.1.107 diacylglycerol kinase epsilon
-
Rattus norvegicus
2.7.1.107 diacylglycerol kinase epsilon
-
Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.107 37
-
assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.107 7.4
-
assay at Rattus norvegicus
2.7.1.107 7.4
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
Rattus norvegicus
2.7.1.107 ATP
-
Bos taurus

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function the enzyme is involved in a mechanism of light-regulated DAGK activity in the photoreceptors of the vertebrate species. Protein kinase C-dependent phosphorylation of retina rod outer segments (obtained from bovine retinas at room light) regulates DAGK activity Bos taurus
2.7.1.107 physiological function the enzyme is involved in a mechanism of light-regulated DAGK activity in the photoreceptors of the vertebrate species. Protein kinase C-dependent phosphorylation of retina rod outer segments regulates DAGK activity Rattus norvegicus