Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Iqbal, Z.; Hameed, S.; Ali, S.; Tehseen, Y.; Shahid, M.; Iqbal, J.
    Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5-imidazolidine]-2,4-diones (2015), Eur. J. Med. Chem., 98, 127-138.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 1'-(4-bromophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 1'-(4-chlorophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 1'-(4-methoxyphenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 1'-(4-methylphenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 1'-(4-nitrophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 1'-(9,10-dioxo-9,10-dihydroanthracen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 1'-(naphthalen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(4-bromophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(4-chlorophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(4-methoxyphenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(4-methylphenylsulfonyl)spiro[fluorene-9,50-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(4-nitrophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(9,10-dioxo-9,10-dihydroanthracen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 3'-(naphthalen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1.1.1.21 additional information synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5-imidazolidine]-2,4-diones, analysis of the Kador-Sharpless model for minimal pharmacophoric requirements for an aldose reductase inhibitor, and superposition of target molecules on a hypoglycemic pharmacophoric model and a aldose reductase pharmacophoric model, overview. Molecular dynamics simulations and inhibitor binding model. Effects of the compounds on diabetic BALB/c mice Bos taurus
1.1.1.21 Valproic acid
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Bos taurus P16116
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.21 native isozymes partially by ammonium sulfate fractionation and dialysis Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 kidney calf Bos taurus
-
1.1.1.21 lens calf Bos taurus
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 AKR1B1
-
 Bos taurus
1.1.1.21 ALR2
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 additional information
-
 inhibition kinetics and thermodynamics, overview Bos taurus additional information