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Literature summary extracted from

  • Lai, D.H.; Poropat, E.; Pravia, C.; Landoni, M.; Couto, A.S.; Rojo, F.G.; Fuchs, A.G.; Dubin, M.; Elingold, I.; Rodriguez, J.B.; Ferella, M.; Esteva, M.I.; Bontempi, E.J.; Lukes, J.
    Solanesyl diphosphate synthase, an enzyme of the ubiquinone synthetic pathway, is required throughout the life cycle of Trypanosoma brucei (2014), Eukaryot. Cell, 13, 320-328.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.85 additional information inhibition of TbSPPS expression by RNAi, inducible by tetracycline, causes effects of TbSPPS RNAi onmRNAand protein levels in the procyclic stage, viability of the BSF cells is also compromised upon RNAi induction, phenotype Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.85 1-[(n-oct-1-ylamino)ethyl] 1,1-bisphosphonic acid strong enzyme inhibitor Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.85 39200
-
 x * 39200, about, sequence calculation Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.85 Trypanosoma brucei Q38EX7 strains 29-13 and TREU927/4, single gene Tb09.160.4300, identical in both strains
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.85 bloodstream form
-
 Trypanosoma brucei
-
2.5.1.85 additional information in the parental 29-13 cells, enzyme TbSPPS is abundantly transcribed Trypanosoma brucei
-

Subunits

EC Number Subunits Comment Organism
2.5.1.85 ? x * 39200, about, sequence calculation Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
2.5.1.85 long-chain solanesyl diphosphate synthase
-
 Trypanosoma brucei
2.5.1.85 solanesyl diphosphate synthase
-
 Trypanosoma brucei
2.5.1.85 TbSPPS
-
 Trypanosoma brucei

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.5.1.85 Trypanosoma brucei sequence calculation
-
 6.12

General Information

EC Number General Information Comment Organism
2.5.1.85 malfunction RNAi-mediated depletion of TbSPPS leads to severe growth inhibition. Ablation of TbSPPS by RNAi will decrease the function of the glycerol-3-phosphate shuttle, which is cured by application of glycerol. The viability of the BSF cells is compromised upon RNAi induction, phenotype overview. Addition of ubiquinone to the medium alleviates the effect of RNAi-mediated depletion of TbSPPS Trypanosoma brucei
2.5.1.85 physiological function solanesyl diphosphate synthase is an enzyme of the ubiquinone synthetic pathway required throughout the life cycle of Trypanosoma brucei Trypanosoma brucei