EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.1.127 | additional information | generation of isozyme ITPKA mutant DELTA1-54 or DELTA1-134. Insertion of the enzyme's catalytic domain inbetween actin filaments increases its inositol-1,4,5-trisphosphate 3-kinase-a activity | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Mg2+ | required | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Homo sapiens | P23677 | gene Itpka | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.127 | More | the N-terminus harbors the actin binding domain, the C-terminus of ITPKA acts as spacer between actin filaments | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.127 | inositol-1,4,5-trisphosphate 3-kinase-A | - |
Homo sapiens |
2.7.1.127 | InsP3Kinase | - |
Homo sapiens |
2.7.1.127 | ITPKA | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.127 | physiological function | isozyme ITPKA induces formation of complex actin networks, but exibits only one N-terminal actin binding domain, the C-terminus of ITPKA acts as spacer between actin filaments, overview. ITPKA induces the formation of a dense network of branched actin filaments, not of linear filaments. Overexpression of ITPKA induces the formation of lamellipodia-like protrusions which consist of cross-linked actin filaments. 1D-myo-inositol 1,3,4,5-tetrakisphosphate inhibits actin polymerization, but does not show a significant effect on bundling activity of ITPKA, while binding of ITPKA to actin stimulates inositol-1,4,5-trisphosphate 3-kinase-a activity | Homo sapiens |