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Literature summary extracted from

  • Rahnasto-Rilla, M.; Kokkola, T.; Jarho, E.; Lahtela-Kakkonen, M.; Moaddel, R.
    N-acylethanolamines bind to SIRT6 (2016), ChemBioChem, 17, 77-81.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.B41 linoleic acid EC50 value of 0.089 mM Homo sapiens
2.3.1.B41 luteolin EC50 value of 0.27 mM Homo sapiens
2.3.1.B41 additional information the enzyme activity is not stimulated by N-stearoylethanolamine and N-arachidonoylethanolamine Homo sapiens
2.3.1.B41 N-(alpha-linolenoyl)ethanolamine
-
 Homo sapiens
2.3.1.B41 N-(gama-linolenoyl)ethanolamine
-
 Homo sapiens
2.3.1.B41 N-linoleoylethanolamine
-
 Homo sapiens
2.3.1.B41 N-myristoylethanolamine
-
 Homo sapiens
2.3.1.B41 N-myristoylethanolamine EC50 value of 0.0075 mM Homo sapiens
2.3.1.B41 N-oleoylethanolamine strongest activator with EC50 value of 0.0031 mM Homo sapiens
2.3.1.B41 N-palmitoleoylethanolamine
-
 Homo sapiens
2.3.1.B41 N-palmitoylethanolamine
-
 Homo sapiens
2.3.1.B41 oleic acid EC50 value of 0.23 mM Homo sapiens
2.3.1.B41 quercetin EC50 value of 0.99 mM Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B41 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.B41 luteolin 30% inhibition at 0.1 mM Homo sapiens
2.3.1.B41 additional information not inhibited by linoleic acid, oleic acid, oleoylethanolamide, and myristoylethanolamide Homo sapiens
2.3.1.B41 quercetin 38% inhibition at 0.1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.B41 0.232
-
 [histone 3]-N6-acetyl-L-lysine9 at pH 8.0 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B41 additional information Homo sapiens the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro ?
-
 ?
2.3.1.B41 NAD+ + [histone 3]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [histone 3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.B41 glutathione agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 additional information the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro Homo sapiens ?
-
 ?
2.3.1.B41 NAD+ + [histone 3]-N6-acetyl-L-lysine9
-
 Homo sapiens nicotinamide + [histone 3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
2.3.1.B41 NAD+ + [histone 3]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [histone 3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 sirtuin 6
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+ dependent on Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.B41 0.0041
-
 at pH 8.0 and 37°C Homo sapiens luteolin
2.3.1.B41 0.024
-
 at pH 8.0 and 37°C Homo sapiens quercetin