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Literature summary extracted from

  • Dippe, M.; Brandt, W.; Rost, H.; Porzel, A.; Schmidt, J.; Wessjohann, L.A.
    Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues (2015), Chem. Commun. (Camb.), 51, 3637-3640.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.6 I105A/I317A the conversion of the natural substrate methionine is reduced in this mutant Bacillus subtilis
2.5.1.6 I105V/I317A the conversion of the natural substrate methionine is reduced in this mutant Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O Bacillus subtilis
-
 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
2.5.1.6 ATP + L-methionine + H2O Bacillus subtilis ATCC 6051
-
 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Bacillus subtilis
-
-
-
2.5.1.6 Bacillus subtilis ATCC 6051
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + D,L-methionine-(methyl-D3) + H2O
-
 Bacillus subtilis ?
-
 ?
2.5.1.6 ATP + D,L-methionine-(methyl-D3) + H2O
-
 Bacillus subtilis ATCC 6051 ?
-
 ?
2.5.1.6 ATP + L-methionine + H2O
-
 Bacillus subtilis phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
2.5.1.6 ATP + L-methionine + H2O
-
 Bacillus subtilis ATCC 6051 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.6 S-adenosylmethionine synthase
-
 Bacillus subtilis
2.5.1.6 SAM synthase
-
 Bacillus subtilis
2.5.1.6 SAMS
-
 Bacillus subtilis