BRENDA - Enzyme Database show

Sirtuin 6 promotes transforming growth factor-beta1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence

Feng, X.X.; Luo, J.; Liu, M.; Yan, W.; Zhou, Z.Z.; Xia, Y.J.; Tu, W.; Li, P.Y.; Feng, Z.H.; Tian, D.A.; Cancer Sci. 106, 559-566 (2015)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
Homo sapiens
-
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.B41
Homo sapiens
Q8N6T7
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.B41
Hep-G2 cell
-
Homo sapiens
-
2.3.1.B41
hepatocellular carcinoma cell
-
Homo sapiens
-
2.3.1.B41
Huh-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
737977
Homo sapiens
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.B41
NAD+
dependent on
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.B41
NAD+
dependent on
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
Homo sapiens
-
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.B41
Hep-G2 cell
-
Homo sapiens
-
2.3.1.B41
hepatocellular carcinoma cell
-
Homo sapiens
-
2.3.1.B41
Huh-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
737977
Homo sapiens
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
2.3.1.B41
Homo sapiens
enzyme expression in HCC cells is upregulated by transforming growth factor-beta1, H2O2, and HOCl
up
General Information
EC Number
General Information
Commentary
Organism
2.3.1.B41
physiological function
the upregulation of SIRT6 expression is required for transforming growth factor-beta1 and H2O2 /HOCl reactive oxygen species to promote the tumorigenicity of hepatocellular carcinoma cells. The enzyme contributes to inhibitory effect of ERK pathway on cellular senescence
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.3.1.B41
physiological function
the upregulation of SIRT6 expression is required for transforming growth factor-beta1 and H2O2 /HOCl reactive oxygen species to promote the tumorigenicity of hepatocellular carcinoma cells. The enzyme contributes to inhibitory effect of ERK pathway on cellular senescence
Homo sapiens
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.3.1.B41
Homo sapiens
enzyme expression in HCC cells is upregulated by transforming growth factor-beta1, H2O2, and HOCl
up