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Literature summary extracted from

  • Payne, A.W.; Pant, D.K.; Pan, T.C.; Chodosh, L.A.
    Ceramide kinase promotes tumor cell survival and mammary tumor recurrence (2014), Cancer Res., 74, 6352-6363.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.138 medicine the enzyme is a therapeutical target in breast cancer treatment due to its functional role in breast cancer recurrence Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.138 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ATP + ceramide Homo sapiens
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens Q8TCT0 gene CERK
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 breast cancer cell CERK expression is associated with an increased risk of recurrence in women with breast cancer Homo sapiens
-
2.7.1.138 BT-20 cell
-
 Homo sapiens
-
2.7.1.138 BT-474 cell
-
 Homo sapiens
-
2.7.1.138 SKBR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.138 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.138 Homo sapiens Cerk is rapidly upregulated in tumor cells following HER2/neu downregulation or treatment with adriamycin down

General Information

EC Number General Information Comment Organism
2.7.1.138 physiological function ceramide kinase promotes tumor cell survival and mammary tumor recurrence. Ceramide kinase is required for mammary tumor recurrence following HER2/neu pathway inhibition and is spontaneously upregulated during tumor recurrence in multiple genetically engineered mouse models for breast cancer. CERK expression is associated with an increased risk of recurrence in women with breast cancer, Cerk promotes tumor cell survival in vivo Homo sapiens