BRENDA - Enzyme Database show

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp

Hwang, B.J.; Jin, J.; Gao, Y.; Shi, G.; Madabushi, A.; Yan, A.; Guan, X.; Zalzman, M.; Nakajima, S.; Lan, L.; Lu, A.L.; BMC Mol. Biol. 16, 12 (2015)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.3.1.B41
expressed in HEK-293T cells
Mus musculus
Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.3.1.B41
G60A
inactive
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.B41
Mus musculus
P59941
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B41
additional information
SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin
737946
Mus musculus
?
-
-
-
-
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
737946
Mus musculus
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.B41
NAD+
dependent on
Mus musculus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.B41
expressed in HEK-293T cells
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.B41
NAD+
dependent on
Mus musculus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.3.1.B41
G60A
inactive
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B41
additional information
SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin
737946
Mus musculus
?
-
-
-
-
2.3.1.B41
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
737946
Mus musculus
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
-
-
?