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Literature summary extracted from

  • Chen, F.; Zhao, Y.; Qi, L.; Fan, C.
    One-step highly sensitive florescence detection of T4 polynucleotide kinase activity and biological small molecules by ligation-nicking coupled reaction-mediated signal amplification (2013), Biosens. Bioelectron., 47, 218-224.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.78 ADP
-
 Tequatrovirus T4
2.7.1.78 ammonium sulfate
-
 Tequatrovirus T4
2.7.1.78 disodium hydrogen phosphate
-
 Tequatrovirus T4

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.78 ATP + 5'-dephospho-DNA Tequatrovirus T4
-
 ADP + 5'-phospho-DNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.78 Tequatrovirus T4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.78 ATP + 5'-dephospho-DNA
-
 Tequatrovirus T4 ADP + 5'-phospho-DNA
-
 ?
2.7.1.78 ATP + 5'-GGCAACAT
-
 Tequatrovirus T4 ?
-
 ?
2.7.1.78 additional information the enzyme shows low activity with ADP, AMP, UTP, GTP, and CTP Tequatrovirus T4 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.78 PNK
-
 Tequatrovirus T4
2.7.1.78 polynucleotide kinase
-
 Tequatrovirus T4

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.78 0.07
-
 at pH 7.0 and 37°C Tequatrovirus T4 ADP