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Literature summary extracted from

  • Wojdyla-Mamori, A.M.; Guranowski, A.
    Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins (2015), Biosci. Rep., 35, e00235.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.51 1.6
-
 adenosine 5'-phosphorofluoridate pH 10.6, 30°C Homo sapiens
2.7.7.51 2.4
-
 adenosine 5'-phosphosulfate pH 10.6, 30°C Homo sapiens
2.7.7.51 60
-
 NH3 cosubstrate adenosine 5'-phosphorofluoridate, pH 10.6, 30°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.51 Homo sapiens O00298 cf. EC 3.6.1.29
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.51 adenosine 5'-phosphorofluoridate + NH3
-
 Homo sapiens adenosine 5'-phosphoramidate + F-
-
 ?
2.7.7.51 adenosine 5'-phosphosulfate + NH3
-
 Homo sapiens adenosine 5'-phosphoramidate + SO42- + H+
-
 ?
2.7.7.51 ApppA + NH3
-
 Homo sapiens adenosine 5'-phosphoramidate + ppA
-
 ?
2.7.7.51 cytidine 5'-phosphosulfate + NH3 91% of the rate with adenosine 5'-phosphosulfate Homo sapiens cytidine 5'-phosphoramidate + SO42- + H+
-
 ?
2.7.7.51 guanosine 5'-phosphosulfate + NH3 47% of the rate with adenosine 5'-phosphosulfate Homo sapiens guanosine 5'-phosphoramidate + SO42- + H+
-
 ?
2.7.7.51 additional information enzyme catalyses ammonolysis of adenosine 5'-phosphosulfate, which results in the formation of adenosine 5'-phosphoramidate. The mechanism for Fhit-catalysed ammonolysis of these substrates most probably involves attack by NH3 on the covalent histidine-bound enzyme-nucleosidyl intermediate. No substrate: adenosine 5'-phosphosulfate-3-phosphate Homo sapiens ?
-
 ?
2.7.7.51 uridine 5'-phosphosulfate + NH3 56% of the rate with adenosine 5'-phosphosulfate Homo sapiens uridine 5'-phosphoramidate + SO42- + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.51 diadenosine triphosphate hydrolase
-
 Homo sapiens
2.7.7.51 Fhit
-
 Homo sapiens
2.7.7.51 Fragile histidine triad protein
-
 Homo sapiens