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Literature summary extracted from

  • Fuchs, C.; Simon, R.; Riethorst, W.; Zepeck, F.; Kroutil, W.
    Synthesis of (R)- or (S)-valinol using omega-transaminases in aqueous and organic media (2014), Bioorg. Med. Chem., 22, 5558-5562.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.6.1.18 synthesis optically pure valinol (ee >99%) is prepared employing different omega-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer are accessible Arabidopsis thaliana
2.6.1.18 synthesis optically pure valinol (ee >99%) is prepared employing different omega-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer are accessible Priestia megaterium
2.6.1.18 synthesis optically pure valinol (ee >99%) is prepared employing different omega-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer are accessible Fusarium graminearum

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.18 Arabidopsis thaliana
-
-
-
2.6.1.18 Fusarium graminearum
-
-
-
2.6.1.18 Priestia megaterium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.18 1-hydroxy-3-methylbutan-2-one + L-alanine
-
 Priestia megaterium (2R)-2-amino-3-methylbutan-1-ol + pyruvate aqueous medium, 99% conversion, 99% ee ?
2.6.1.18 1-hydroxy-3-methylbutan-2-one + L-alanine
-
 Arabidopsis thaliana (2S)-2-amino-3-methylbutan-1-ol + pyruvate aqueous medium, 99% conversion, 99% ee ?
2.6.1.18 1-hydroxy-3-methylbutan-2-one + L-alanine
-
 Fusarium graminearum (2S)-2-amino-3-methylbutan-1-ol + pyruvate aqueous medium, 99% conversion, 99% ee ?