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Literature summary extracted from

  • Saito, R.; Suzuki, S.; Sasaki, K.
    Pterin-7-carboxamides as a new class of aldose reductase inhibitors (2016), Bioorg. Med. Chem. Lett., 26, 4870-4874.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid
-
 Homo sapiens
1.1.1.21 2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
-
 Homo sapiens
1.1.1.21 2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
-
 Homo sapiens
1.1.1.21 4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
-
 Homo sapiens
1.1.1.21 5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
-
 Homo sapiens
1.1.1.21 6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
-
 Homo sapiens
1.1.1.21 epalrestat
-
 Homo sapiens
1.1.1.21 folic acid
-
 Homo sapiens
1.1.1.21 additional information analysis of pterin-7-carboxamides as aldose reductase inhibitors, evaluation of the inhibitory activity of the compounds Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine
-
 Homo sapiens
1.1.1.21 N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanine 9% inhibition at 10.5 mM Homo sapiens
1.1.1.21 sorbinil
-
 Homo sapiens
1.1.1.21 [(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens P15121
-
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 AKR1B1 gene name, UniProt Homo sapiens
1.1.1.21 aldose reductase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0000665
-
 pH and temperature not specified in the publication Homo sapiens epalrestat
1.1.1.21 0.00197
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine
1.1.1.21 0.00402
-
 pH and temperature not specified in the publication Homo sapiens 6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
1.1.1.21 0.0117
-
 pH and temperature not specified in the publication Homo sapiens 5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
1.1.1.21 0.0124
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine
1.1.1.21 0.0175
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine
1.1.1.21 0.0251
-
 pH and temperature not specified in the publication Homo sapiens 2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
1.1.1.21 0.0255
-
 pH and temperature not specified in the publication Homo sapiens 4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
1.1.1.21 0.0265
-
 pH and temperature not specified in the publication Homo sapiens 2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
1.1.1.21 0.0292
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine
1.1.1.21 0.0426
-
 pH and temperature not specified in the publication Homo sapiens [(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid
1.1.1.21 0.046
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
1.1.1.21 0.0525
-
 pH and temperature not specified in the publication Homo sapiens folic acid
1.1.1.21 0.0617
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine
1.1.1.21 0.069
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine
1.1.1.21 0.0834
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine
1.1.1.21 0.216
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine