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Literature summary extracted from

  • Sugimoto, M.; Shimizu, Y.; Zhao, S.; Ukon, N.; Nishijima, K.; Wakabayashi, M.; Yoshioka, T.; Higashino, K.; Numata, Y.; Okuda, T.; Tamaki, N.; Hanamatsu, H.; Igarashi, Y.; Kuge, Y.
    Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice (2016), Biochim. Biophys. Acta, 1861, 688-702.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.8.27 pharmacology sphingomyelin synthase 2 (SMS2) is a potential therapeutic target for obesity and insulin resistance Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 gene Sgms2, relative real-time PCR expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.27 additional information generation of SMS2 KO mice Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 a ceramide + a phosphatidylcholine Mus musculus
-
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
?
2.7.8.27 a ceramide + a phosphatidylcholine Mus musculus C57BL/6N
-
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Mus musculus Q9D4B1
-
-
2.7.8.27 Mus musculus C57BL/6N Q9D4B1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 liver
-
Mus musculus
-
2.7.8.27 skeletal muscle
-
Mus musculus
-
2.7.8.27 white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 a ceramide + a phosphatidylcholine
-
Mus musculus a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
?
2.7.8.27 a ceramide + a phosphatidylcholine
-
Mus musculus C57BL/6N a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 Sgms2
-
Mus musculus
2.7.8.27 SMS2
-
Mus musculus
2.7.8.27 sphingomyelin synthase 2
-
Mus musculus

General Information

EC Number General Information Comment Organism
2.7.8.27 malfunction glucose kinetics study using the radiolabeled glucose analog 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG), in wild-type (WT) and SMS2 knockout (KO) mice: insulin signaling is enhanced in the liver, white adipose tissue and skeletal muscle of SMS2 KO mice compared with those of wild-type mice. In addition, compared with in wild-type mice, blood clearance of 18F-FDG is accelerated in SMS2 KO mice when they are fed either a normal or a high fat diet. 18F-FDG uptake is also increased in insulin-targeted tissues such as skeletal muscle in the SMS2 KO mice, whereas skeletal muscle sphingolipid content is not clearly affected. Plasma levels of very long-chain fatty acid (VLCFA)-containing ceramides are markedly increased in SMS2 KO mice compared with in wild-type mice. Genetic inhibition of SMS2 elevates glucose clearance through activation of glucose uptake into insulin-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2. This occurs, at least in part, via indirect mechanisms such as elevation of VLCFA-containing ceramides Mus musculus
2.7.8.27 physiological function role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice Mus musculus