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Literature summary extracted from

  • Li, Z.; Wu, G.; van der Veen, J.N.; Hermansson, M.; Vance, D.E.
    Phosphatidylcholine metabolism and choline kinase in human osteoblasts (2014), Biochim. Biophys. Acta, 1841, 859-867.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.32 ATP + choline Homo sapiens
-
 ADP + phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens P35790
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.32 MG-63 cell
-
 Homo sapiens
-
2.7.1.32 osteoblast
-
 Homo sapiens
-
2.7.1.32 osteosarcoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
 Homo sapiens ADP + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 choline kinase alpha
-
 Homo sapiens
2.7.1.32 CK-alpha
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.32 Homo sapiens choline kinase activity and expression in MG-63 cells are significantly higher than those in primary human osteoblasts up

General Information

EC Number General Information Comment Organism
2.7.1.32 malfunction the silencing of choline kinase alpha reduces cell proliferation. Moreover, pharmacological inhibition of choline kinase activity impairs the mineralization capacity of MG-63 cells Homo sapiens
2.7.1.32 physiological function choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells Homo sapiens