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Literature summary extracted from

  • Corpas, F.J.; Leterrier, M.; Begara-Morales, J.C.; Valderrama, R.; Chaki, M.; Lopez-Jaramillo, J.; Luque, F.; Palma, J.M.; Padilla, M.N.; Sanchez-Calvo, B.; Mata-Perez, C.; Barroso, J.B.
    Inhibition of peroxisomal hydroxypyruvate reductase (HPR1) by tyrosine nitration (2013), Biochim. Biophys. Acta, 1830, 4981-4989.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.29 expressed in Escherichia coli strain BIVU0811 Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.29 GSH about 72% residual activity at 2 mM Arabidopsis thaliana
1.1.1.29 additional information not inhibited by H2O2 Arabidopsis thaliana
1.1.1.29 S-nitrosoglutathione about 80% residual activity at 2 mM Arabidopsis thaliana
1.1.1.29 SIN-1 about 35% residual activity at 1 mM Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.29 peroxisome
-
 Arabidopsis thaliana 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.29 42300
-
-
 Arabidopsis thaliana
1.1.1.29 63500
-
-
 Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.29 hydroxypyruvate + NADH + H+ Arabidopsis thaliana
-
 D-glycerate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.29 Arabidopsis thaliana Q9C9W5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.29 LYTRA column chromatography, and Superdex 200 gel filtration Arabidopsis thaliana

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.29 0.0051
-
 recombinant enzyme, at pH and °C Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.29 hydroxypyruvate + NADH + H+
-
 Arabidopsis thaliana D-glycerate + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.29 ? x * 42300, calculated from amino acid sequence Arabidopsis thaliana
1.1.1.29 ? x * 63500, enzyme with N-terminal choline binding domain, SDS-PAGE Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
1.1.1.29 HPR1
-
 Arabidopsis thaliana
1.1.1.29 hydroxypyruvate reductase
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.29 NADH
-
 Arabidopsis thaliana