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Literature summary extracted from

  • Franco-Echevarria, E.; Banos-Sanz, J.I.; Monterroso, B.; Round, A.; Sanz-Aparicio, J.; Gonzalez, B.
    A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation (2014), Biochem. J., 463, 319-328.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.127 Calmodulin the enzyme is activated by Ca2+/calmodulin. The human isozyme IP3-3K A contains a CaM binding domain at residues 158-183, binding structure and identification all of the key residues involved in the interaction, overview Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.127 crystal structure of the complex between human Ca2+/CaM and the CaM-binding region of human IP3-3K isoform A (residues 158-183), modeling of the complex including the kinase domain Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ the enzyme is activated by Ca2+/calmodulin Homo sapiens
2.7.1.127 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Homo sapiens P23677 isozyme/gene ITPKA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 ITPKA
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.127 physiological function 1D-myo-inositol 1,4,5-trisphosphate is a key point in Ca2+ metabolism that promotes Ca2+ release from intracellular stores and together with 1D-myo-inositol 1,3,4,5-tetrakisphosphate regulates Ca2+ homoeostasis. In addition, 1D-myo-inositol 1,3,4,5-tetrakisphosphate is involved in immune cell development. Ca2+ and calmodulin regulate the activity of inositol(1,4,5)trisphosphate 3-kinases via direct interaction Homo sapiens