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Literature summary extracted from

  • Rybniker, J.; Pojer, F.; Marienhagen, J.; Kolly, G.S.; Chen, J.M.; van Gumpel, E.; Hartmann, P.; Cole, S.T.
    The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence (2014), Biochem. J., 459, 467-478.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.7 L-cysteine + acceptor Mycobacterium tuberculosis
-
 L-alanine + S-sulfanyl-acceptor
-
 ?
2.8.1.7 L-cysteine + acceptor Mycobacterium tuberculosis Rv3025c
-
 L-alanine + S-sulfanyl-acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.7 Mycobacterium tuberculosis
-
-
-
2.8.1.7 Mycobacterium tuberculosis Rv3025c
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.7 L-cysteine + acceptor
-
 Mycobacterium tuberculosis L-alanine + S-sulfanyl-acceptor
-
 ?
2.8.1.7 L-cysteine + acceptor
-
 Mycobacterium tuberculosis Rv3025c L-alanine + S-sulfanyl-acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.7 IscS
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.8.1.7 malfunction deleting the enzyme renders the cells microaerophilic and hypersensitive to oxidative stress. Moreover, the deletion mutant shows impaired Fe-S cluster-dependent enzyme activity Mycobacterium tuberculosis
2.8.1.7 physiological function the enzyme is involved in iron-sulfur cluster biogenesis and oxidative stress defence Mycobacterium tuberculosis