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Literature summary extracted from

  • Clarke, J.H.; Irvine, R.F.
    Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization (2013), Biochem. J., 454, 49-57.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.149 D280K inactive Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.149 0.00394
-
 ATP isoform PI5P4Kalpha, at pH 7.4 and 22°C Homo sapiens
2.7.1.149 0.00394
-
 ATP isoform PI5P4Kalpha, at pH 7.4 and 30°C Homo sapiens
2.7.1.149 0.06705
-
 ATP isoform PI5P4Kbeta, at pH 7.4 and 22°C Homo sapiens
2.7.1.149 0.06705
-
 ATP isoform PI5P4Kbeta, at pH 7.4 and 30°C Homo sapiens
2.7.1.149 0.09418
-
 ATP isoform PI5P4Kgamma, at pH 7.4 and 22°C Homo sapiens
2.7.1.149 0.09418
-
 ATP isoform PI5P4Kgamma, at pH 7.4 and 30°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.149 nucleus
-
 Homo sapiens 5634
-
2.7.1.149 nucleus isoform PI5P4Kbeta Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.149 47000
-
 x * 47000, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.149 Homo sapiens P48426
-
-
2.7.1.149 Homo sapiens P78356
-
-
2.7.1.149 Homo sapiens Q8TBX8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.149 ? x * 47000, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.149 phosphatidylinositol 5-phosphate 4-kinase
-
 Homo sapiens
2.7.1.149 PI5P4Kalpha
-
 Homo sapiens
2.7.1.149 PI5P4Kalpha isoform Homo sapiens
2.7.1.149 PI5P4Kbeta
-
 Homo sapiens
2.7.1.149 PI5P4Kbeta isoform Homo sapiens
2.7.1.149 PI5P4Kgamma
-
 Homo sapiens
2.7.1.149 PI5P4Kgamma isoform Homo sapiens
2.7.1.149 PtdIns5P 4-kinase
-
 Homo sapiens
2.7.1.149 PtdIns5P4-kinase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.149 0.00000572
-
 ATP isoform PI5P4Kgamma, at pH 7.4 and 22°C Homo sapiens
2.7.1.149 0.000955
-
 ATP isoform PI5P4Kbeta, at pH 7.4 and 22°C Homo sapiens
2.7.1.149 0.0105
-
 ATP isoform PI5P4Kalpha, at pH 7.4 and 22°C Homo sapiens