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Literature summary extracted from

  • Sun, R.; Eriksson, S.; Wang, L.
    Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs (2014), Biochem. Biophys. Res. Commun., 450, 1021-1026.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.113 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine Homo sapiens
-
 ADP + dGMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.113 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.113 U2OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine
-
 Homo sapiens ADP + dGMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.113 DGK
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.113 Homo sapiens enzyme expression is downregulated by didanosine (2',3'-dideoxyinosine) to about 40% down