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Literature summary extracted from

  • Melkonyan, L.; Avetisova, G.; Hambardzumyan, A.; Chakhalyan, A.; Saghyan, A.
    Study of regulation of some key enzymes of L-alanine biosynthesis by Brevibacterium flavum producer strains (2013), Appl. Biochem. Microbiol., 49, 120-124.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.2 beta-chloro-L-alanine
-
 [Brevibacterium] flavum
2.6.1.2 DL-2-aminobutanoate
-
 [Brevibacterium] flavum
2.6.1.2 L-Cycloserine
-
 [Brevibacterium] flavum
2.6.1.66 beta-chloro-L-alanine
-
 [Brevibacterium] flavum
2.6.1.66 DL-alpha-aminobutanoate
-
 [Brevibacterium] flavum
2.6.1.66 L-Cycloserine
-
 [Brevibacterium] flavum

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.2 [Brevibacterium] flavum
-
-
-
2.6.1.2 [Brevibacterium] flavum ATCC 14067
-
-
-
2.6.1.66 [Brevibacterium] flavum
-
-
-
2.6.1.66 [Brevibacterium] flavum ATCC 14067
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.2 L-alanine + 2-oxoglutarate
-
 [Brevibacterium] flavum pyruvate + L-glutamate
-
 ?
2.6.1.2 L-alanine + 2-oxoglutarate
-
 [Brevibacterium] flavum ATCC 14067 pyruvate + L-glutamate
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.2 0.15
-
 pH 8.0, temperature not specified in the publication [Brevibacterium] flavum beta-chloro-L-alanine
2.6.1.2 1.3
-
 pH 8.0, temperature not specified in the publication [Brevibacterium] flavum L-Cycloserine
2.6.1.2 68
-
 pH 8.0, temperature not specified in the publication [Brevibacterium] flavum DL-2-aminobutanoate
2.6.1.66 4.1
-
 pH 8.0, temperature not specified in the publication [Brevibacterium] flavum L-Cycloserine
2.6.1.66 20
-
 above 20 mM, pH 8.0, temperature not specified in the publication [Brevibacterium] flavum beta-chloro-L-alanine
2.6.1.66 80
-
 above 80 mM, pH 8.0, temperature not specified in the publication [Brevibacterium] flavum DL-alpha-aminobutanoate