EC Number | Application | Comment | Organism |
---|---|---|---|
2.5.1.B31 | synthesis | possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 5-DMATS, overview | Aspergillus clavatus |
2.5.1.B31 | synthesis | possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 5-DMATSSc, overview | Streptomyces coelicolor |
2.5.1.34 | synthesis | possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 4-DMATS, overview | Aspergillus fumigatus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.B31 | recombinant overexpression | Streptomyces coelicolor |
2.5.1.B31 | recombinant overexpression | Aspergillus clavatus |
2.5.1.80 | recombinant overexpression | Aspergillus fumigatus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.5.1.34 | M328L | site-directed mutagenesis, the FgaPT2 mutant shows increased activity with L-tyrosine compared to the wild-type enzyme | Aspergillus fumigatus |
2.5.1.34 | Y398F | site-directed mutagenesis, the FgaPT2 mutant shows increased activity with L-tyrosine compared to the wild-type enzyme | Aspergillus fumigatus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.B31 | 0.2 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Streptomyces coelicolor | |
2.5.1.B31 | 0.2 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus clavatus | |
2.5.1.B31 | 0.21 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Streptomyces coelicolor | |
2.5.1.B31 | 0.21 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus clavatus | |
2.5.1.34 | 0.011 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus fumigatus | |
2.5.1.34 | 0.032 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus fumigatus | |
2.5.1.34 | 0.055 | - |
dia-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus fumigatus | |
2.5.1.80 | 0.1 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus | |
2.5.1.80 | 0.14 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus | |
2.5.1.80 | 0.18 | - |
dia-ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus | |
2.5.1.80 | 0.34 | - |
dia,ent-ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.B31 | Ca2+ | required | Streptomyces coelicolor | |
2.5.1.B31 | Ca2+ | required | Aspergillus clavatus | |
2.5.1.80 | Ca2+ | required | Aspergillus fumigatus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.B31 | dimethylallyl diphosphate + L-tryptophan | Aspergillus clavatus | - |
diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + L-tryptophan | Streptomyces coelicolor | - |
diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | the product is further processed to 5-dimethylallylindole-3-acetonitrile | ? | |
2.5.1.B31 | additional information | Aspergillus clavatus | dimethylallyltryptophan synthases (DMATSs) catalyze regiospecific transfer reactions of a prenyl moiety from dimethylallyl diphosphate to various positions of the indole ring of tryptophan | ? | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + L-tryptophan | Aspergillus fumigatus | - |
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + L-tryptophan | Aspergillus fumigatus | - |
diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + L-tryptophan | Aspergillus fumigatus ATCC MYA-4609 | - |
diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.B31 | Aspergillus clavatus | - |
gene 5-DMATS | - |
2.5.1.B31 | Streptomyces coelicolor | - |
gene 5-DMATS | - |
2.5.1.34 | Aspergillus fumigatus | Q50EL0 | gene 4-DMATS | - |
2.5.1.80 | Aspergillus fumigatus | Q4WYG3 | - |
- |
2.5.1.80 | Aspergillus fumigatus ATCC MYA-4609 | Q4WYG3 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.B31 | recombinant enzyme | Streptomyces coelicolor |
2.5.1.B31 | recombinant enzyme | Aspergillus clavatus |
2.5.1.80 | recombinant enzyme | Aspergillus fumigatus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.B31 | dimethylallyl diphosphate + ardeemin fumiquinazoline | - |
Aspergillus clavatus | diphosphate + (1S,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + ardeemin fumiquinazoline | - |
Streptomyces coelicolor | diphosphate + (1S,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-1-[[5,6-bis(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-4-methyl-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline | - |
Aspergillus clavatus | diphosphate + (1R,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline | - |
Streptomyces coelicolor | diphosphate + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + dia-ardeemin fumiquinazoline | - |
Aspergillus clavatus | diphosphate + (1S,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + dia-ardeemin fumiquinazoline | - |
Streptomyces coelicolor | diphosphate + (1S,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + ent-ardeemin fumiquinazoline | - |
Aspergillus clavatus | diphosphate + (1R,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + ent-ardeemin fumiquinazoline | - |
Streptomyces coelicolor | diphosphate + (1R,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-1-[[5,6-bis(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-4-methyl-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + L-tryptophan | - |
Streptomyces coelicolor | diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus clavatus | diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + L-tryptophan | - |
Streptomyces coelicolor | diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | the product is further processed to 5-dimethylallylindole-3-acetonitrile | ? | |
2.5.1.B31 | dimethylallyl diphosphate + L-tyrosine | - |
Streptomyces coelicolor | diphosphate + 3-(3-methylbut-2-enyl)-L-tyrosine | - |
? | |
2.5.1.B31 | dimethylallyl diphosphate + L-tyrosine | - |
Aspergillus clavatus | diphosphate + 3-(3-methylbut-2-enyl)-L-tyrosine | - |
? | |
2.5.1.B31 | additional information | dimethylallyltryptophan synthases (DMATSs) catalyze regiospecific transfer reactions of a prenyl moiety from dimethylallyl diphosphate to various positions of the indole ring of tryptophan | Aspergillus clavatus | ? | - |
? | |
2.5.1.B31 | additional information | 5-DMATS catalyzes regiospecific prenylation of analogues of ardeemin fumiquinazoline. Synthesis of ardeemin fumiquinazoline, a precursor of the multidrug resistance export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview | Aspergillus clavatus | ? | - |
? | |
2.5.1.B31 | additional information | 5-DMATSSc catalyzes regiospecific prenylation of analogues of ardeemin fumiquinazoline. Synthesis of ardeemin FQ, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview | Streptomyces coelicolor | ? | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1S,4R)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1R,4R)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + dia-ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1S,4S)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + ent-ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1R,4S)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus fumigatus | diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.34 | dimethylallyl diphosphate + L-tyrosine | low activity with the wild-type enzyme, higher activity with the enzyme mutantsM328L and Y398F | Aspergillus fumigatus | diphosphate + 3-(3-methylbut-2-enyl)-L-tyrosine | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + ardeemin fumiquinazoline | - |
Aspergillus fumigatus ATCC MYA-4609 | diphosphate + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline | - |
Aspergillus fumigatus ATCC MYA-4609 | diphosphate + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + dia-ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1S,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4S)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + ent-ardeemin fumiquinazoline | - |
Aspergillus fumigatus | diphosphate + (1R,4S)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus fumigatus | diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus fumigatus ATCC MYA-4609 | diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus fumigatus | diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.80 | dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus fumigatus ATCC MYA-4609 | diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
2.5.1.80 | additional information | 7-DMATS catalyzes mainly regiospecific prenylation at C-7 of analogues of ardeemin fumiquinazoline, which is also observed for its natural substrate L-tryptophan. Synthesis of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview | Aspergillus fumigatus | ? | - |
? | |
2.5.1.80 | additional information | 7-DMATS catalyzes mainly regiospecific prenylation at C-7 of analogues of ardeemin fumiquinazoline, which is also observed for its natural substrate L-tryptophan. Synthesis of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview | Aspergillus fumigatus ATCC MYA-4609 | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.B31 | 5-DMATS | - |
Aspergillus clavatus |
2.5.1.B31 | 5-DMATSSc | - |
Streptomyces coelicolor |
2.5.1.34 | 4-DMATS | - |
Aspergillus fumigatus |
2.5.1.34 | FgaPT2 | - |
Aspergillus fumigatus |
2.5.1.80 | 7-DMATS | - |
Aspergillus fumigatus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.B31 | 37 | - |
assay at | Streptomyces coelicolor |
2.5.1.B31 | 37 | - |
assay at | Aspergillus clavatus |
2.5.1.34 | 37 | - |
assay at | Aspergillus fumigatus |
2.5.1.80 | 37 | - |
assay at | Aspergillus fumigatus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.B31 | 37 | - |
purified recombinant enzyme, loss of 50% activity after 20 min, loss of over 90% activity after 60 min, inactivation after 120 min | Streptomyces coelicolor |
2.5.1.34 | 37 | - |
purified enzyme, pH 7.5, 4 h, 20% activity remaining | Aspergillus fumigatus |
2.5.1.80 | 37 | - |
the purified recombinant enzyme retains 90% activity after 240 min | Aspergillus fumigatus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.B31 | 0.022 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Streptomyces coelicolor | |
2.5.1.B31 | 0.022 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus clavatus | |
2.5.1.B31 | 0.027 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Streptomyces coelicolor | |
2.5.1.B31 | 0.027 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus clavatus | |
2.5.1.34 | 0.0016 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus fumigatus | |
2.5.1.34 | 0.009 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus fumigatus | |
2.5.1.34 | 0.009 | - |
dia-ardeemin fumiquinazoline | pH 7.5, 37°C, wild-type enzyme | Aspergillus fumigatus | |
2.5.1.80 | 0.002 | - |
dia,ent-ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus | |
2.5.1.80 | 0.053 | - |
dia-ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus | |
2.5.1.80 | 0.059 | - |
ent-ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus | |
2.5.1.80 | 0.079 | - |
ardeemin fumiquinazoline | pH 7.5, 37°C | Aspergillus fumigatus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.B31 | 7.5 | - |
assay at | Streptomyces coelicolor |
2.5.1.B31 | 7.5 | - |
assay at | Aspergillus clavatus |
2.5.1.34 | 7.5 | - |
assay at | Aspergillus fumigatus |
2.5.1.80 | 7.5 | - |
assay at | Aspergillus fumigatus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.B31 | metabolism | enzyme 5-DMATSSc enzyme is involved in biosynthesis of dimethylallylindole 3-acetonitrile | Streptomyces coelicolor |
2.5.1.B31 | additional information | possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 5-DMATSSc | Streptomyces coelicolor |
2.5.1.34 | metabolism | dimethylallyltryptophan synthases (DMATSs) catalyze regiospecific transfer reactions of a prenyl moiety from dimethylallyl diphosphate to various positions of the indole ring of tryptophan. The 4-DMATS enzyme FgaPT2 is involved in biosynthesis of fumigaclavine C | Aspergillus fumigatus |
2.5.1.34 | additional information | possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 4-DMATS, docking study of FgaPT2 with ardeemin fumiquinazoline and its stereoisomers, overview | Aspergillus fumigatus |
2.5.1.80 | physiological function | the enzyme is involved in the biosynthesis of astechrome in Aspergillus fumigatus | Aspergillus fumigatus |