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Literature summary extracted from

  • Mai, P.; Zocher, G.; Ludwig, L.; Stehle, T.; Li, S.
    Actions of tryptophan prenyltransferases toward fumiquinazolines and their potential application for the generation of prenylated derivatives by combining chemical and chemoenzymatic syntheses (2016), Adv. Synth. Catal., 358, 1639 -1653.
No PubMed abstract available

Application

EC Number Application Comment Organism
2.5.1.B31 synthesis possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 5-DMATS, overview Aspergillus clavatus
2.5.1.B31 synthesis possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 5-DMATSSc, overview Streptomyces coelicolor
2.5.1.34 synthesis possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 4-DMATS, overview Aspergillus fumigatus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.B31 recombinant overexpression Streptomyces coelicolor
2.5.1.B31 recombinant overexpression Aspergillus clavatus
2.5.1.80 recombinant overexpression Aspergillus fumigatus

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.34 M328L site-directed mutagenesis, the FgaPT2 mutant shows increased activity with L-tyrosine compared to the wild-type enzyme Aspergillus fumigatus
2.5.1.34 Y398F site-directed mutagenesis, the FgaPT2 mutant shows increased activity with L-tyrosine compared to the wild-type enzyme Aspergillus fumigatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.B31 0.2
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Streptomyces coelicolor
2.5.1.B31 0.2
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus clavatus
2.5.1.B31 0.21
-
ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Streptomyces coelicolor
2.5.1.B31 0.21
-
ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus clavatus
2.5.1.34 0.011
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus fumigatus
2.5.1.34 0.032
-
ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus fumigatus
2.5.1.34 0.055
-
dia-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus fumigatus
2.5.1.80 0.1
-
ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus
2.5.1.80 0.14
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus
2.5.1.80 0.18
-
dia-ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus
2.5.1.80 0.34
-
dia,ent-ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.B31 Ca2+ required Streptomyces coelicolor
2.5.1.B31 Ca2+ required Aspergillus clavatus
2.5.1.80 Ca2+ required Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.B31 dimethylallyl diphosphate + L-tryptophan Aspergillus clavatus
-
diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.B31 dimethylallyl diphosphate + L-tryptophan Streptomyces coelicolor
-
diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan the product is further processed to 5-dimethylallylindole-3-acetonitrile ?
2.5.1.B31 additional information Aspergillus clavatus dimethylallyltryptophan synthases (DMATSs) catalyze regiospecific transfer reactions of a prenyl moiety from dimethylallyl diphosphate to various positions of the indole ring of tryptophan ?
-
?
2.5.1.34 dimethylallyl diphosphate + L-tryptophan Aspergillus fumigatus
-
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.80 dimethylallyl diphosphate + L-tryptophan Aspergillus fumigatus
-
diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.80 dimethylallyl diphosphate + L-tryptophan Aspergillus fumigatus ATCC MYA-4609
-
diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.B31 Aspergillus clavatus
-
gene 5-DMATS
-
2.5.1.B31 Streptomyces coelicolor
-
gene 5-DMATS
-
2.5.1.34 Aspergillus fumigatus Q50EL0 gene 4-DMATS
-
2.5.1.80 Aspergillus fumigatus Q4WYG3
-
-
2.5.1.80 Aspergillus fumigatus ATCC MYA-4609 Q4WYG3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.B31 recombinant enzyme Streptomyces coelicolor
2.5.1.B31 recombinant enzyme Aspergillus clavatus
2.5.1.80 recombinant enzyme Aspergillus fumigatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.B31 dimethylallyl diphosphate + ardeemin fumiquinazoline
-
Aspergillus clavatus diphosphate + (1S,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + ardeemin fumiquinazoline
-
Streptomyces coelicolor diphosphate + (1S,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-1-[[5,6-bis(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-4-methyl-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline
-
Aspergillus clavatus diphosphate + (1R,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline
-
Streptomyces coelicolor diphosphate + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + dia-ardeemin fumiquinazoline
-
Aspergillus clavatus diphosphate + (1S,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + dia-ardeemin fumiquinazoline
-
Streptomyces coelicolor diphosphate + (1S,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + ent-ardeemin fumiquinazoline
-
Aspergillus clavatus diphosphate + (1R,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + ent-ardeemin fumiquinazoline
-
Streptomyces coelicolor diphosphate + (1R,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-1-[[5,6-bis(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-4-methyl-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.B31 dimethylallyl diphosphate + L-tryptophan
-
Streptomyces coelicolor diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.B31 dimethylallyl diphosphate + L-tryptophan
-
Aspergillus clavatus diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.B31 dimethylallyl diphosphate + L-tryptophan
-
Streptomyces coelicolor diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan the product is further processed to 5-dimethylallylindole-3-acetonitrile ?
2.5.1.B31 dimethylallyl diphosphate + L-tyrosine
-
Streptomyces coelicolor diphosphate + 3-(3-methylbut-2-enyl)-L-tyrosine
-
?
2.5.1.B31 dimethylallyl diphosphate + L-tyrosine
-
Aspergillus clavatus diphosphate + 3-(3-methylbut-2-enyl)-L-tyrosine
-
?
2.5.1.B31 additional information dimethylallyltryptophan synthases (DMATSs) catalyze regiospecific transfer reactions of a prenyl moiety from dimethylallyl diphosphate to various positions of the indole ring of tryptophan Aspergillus clavatus ?
-
?
2.5.1.B31 additional information 5-DMATS catalyzes regiospecific prenylation of analogues of ardeemin fumiquinazoline. Synthesis of ardeemin fumiquinazoline, a precursor of the multidrug resistance export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview Aspergillus clavatus ?
-
?
2.5.1.B31 additional information 5-DMATSSc catalyzes regiospecific prenylation of analogues of ardeemin fumiquinazoline. Synthesis of ardeemin FQ, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview Streptomyces coelicolor ?
-
?
2.5.1.34 dimethylallyl diphosphate + ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1S,4R)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.34 dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1R,4R)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.34 dimethylallyl diphosphate + dia-ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1S,4S)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.34 dimethylallyl diphosphate + ent-ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1R,4S)-4-methyl-1-[[4-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.34 dimethylallyl diphosphate + L-tryptophan
-
Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.34 dimethylallyl diphosphate + L-tyrosine low activity with the wild-type enzyme, higher activity with the enzyme mutantsM328L and Y398F Aspergillus fumigatus diphosphate + 3-(3-methylbut-2-enyl)-L-tyrosine
-
?
2.5.1.80 dimethylallyl diphosphate + ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.80 dimethylallyl diphosphate + ardeemin fumiquinazoline
-
Aspergillus fumigatus ATCC MYA-4609 diphosphate + (1S,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.80 dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.80 dimethylallyl diphosphate + dia,ent-ardeemin fumiquinazoline
-
Aspergillus fumigatus ATCC MYA-4609 diphosphate + (1R,4R)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1R,4R)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.80 dimethylallyl diphosphate + dia-ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1S,4S)-4-methyl-1-[[6-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione + (1S,4S)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.80 dimethylallyl diphosphate + ent-ardeemin fumiquinazoline
-
Aspergillus fumigatus diphosphate + (1R,4S)-4-methyl-1-[[7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl]-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione
-
?
2.5.1.80 dimethylallyl diphosphate + L-tryptophan
-
Aspergillus fumigatus diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.80 dimethylallyl diphosphate + L-tryptophan
-
Aspergillus fumigatus ATCC MYA-4609 diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.80 dimethylallyl diphosphate + L-tryptophan
-
Aspergillus fumigatus diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.80 dimethylallyl diphosphate + L-tryptophan
-
Aspergillus fumigatus ATCC MYA-4609 diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
-
?
2.5.1.80 additional information 7-DMATS catalyzes mainly regiospecific prenylation at C-7 of analogues of ardeemin fumiquinazoline, which is also observed for its natural substrate L-tryptophan. Synthesis of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview Aspergillus fumigatus ?
-
?
2.5.1.80 additional information 7-DMATS catalyzes mainly regiospecific prenylation at C-7 of analogues of ardeemin fumiquinazoline, which is also observed for its natural substrate L-tryptophan. Synthesis of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, and its stereoisomers, LC-MS analysis of reaction products, overview Aspergillus fumigatus ATCC MYA-4609 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.B31 5-DMATS
-
Aspergillus clavatus
2.5.1.B31 5-DMATSSc
-
Streptomyces coelicolor
2.5.1.34 4-DMATS
-
Aspergillus fumigatus
2.5.1.34 FgaPT2
-
Aspergillus fumigatus
2.5.1.80 7-DMATS
-
Aspergillus fumigatus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.B31 37
-
assay at Streptomyces coelicolor
2.5.1.B31 37
-
assay at Aspergillus clavatus
2.5.1.34 37
-
assay at Aspergillus fumigatus
2.5.1.80 37
-
assay at Aspergillus fumigatus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.5.1.B31 37
-
purified recombinant enzyme, loss of 50% activity after 20 min, loss of over 90% activity after 60 min, inactivation after 120 min Streptomyces coelicolor
2.5.1.34 37
-
purified enzyme, pH 7.5, 4 h, 20% activity remaining Aspergillus fumigatus
2.5.1.80 37
-
the purified recombinant enzyme retains 90% activity after 240 min Aspergillus fumigatus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.B31 0.022
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Streptomyces coelicolor
2.5.1.B31 0.022
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus clavatus
2.5.1.B31 0.027
-
ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Streptomyces coelicolor
2.5.1.B31 0.027
-
ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus clavatus
2.5.1.34 0.0016
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus fumigatus
2.5.1.34 0.009
-
ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus fumigatus
2.5.1.34 0.009
-
dia-ardeemin fumiquinazoline pH 7.5, 37°C, wild-type enzyme Aspergillus fumigatus
2.5.1.80 0.002
-
dia,ent-ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus
2.5.1.80 0.053
-
dia-ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus
2.5.1.80 0.059
-
ent-ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus
2.5.1.80 0.079
-
ardeemin fumiquinazoline pH 7.5, 37°C Aspergillus fumigatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.B31 7.5
-
assay at Streptomyces coelicolor
2.5.1.B31 7.5
-
assay at Aspergillus clavatus
2.5.1.34 7.5
-
assay at Aspergillus fumigatus
2.5.1.80 7.5
-
assay at Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
2.5.1.B31 metabolism enzyme 5-DMATSSc enzyme is involved in biosynthesis of dimethylallylindole 3-acetonitrile Streptomyces coelicolor
2.5.1.B31 additional information possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 5-DMATSSc Streptomyces coelicolor
2.5.1.34 metabolism dimethylallyltryptophan synthases (DMATSs) catalyze regiospecific transfer reactions of a prenyl moiety from dimethylallyl diphosphate to various positions of the indole ring of tryptophan. The 4-DMATS enzyme FgaPT2 is involved in biosynthesis of fumigaclavine C Aspergillus fumigatus
2.5.1.34 additional information possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 4-DMATS, docking study of FgaPT2 with ardeemin fumiquinazoline and its stereoisomers, overview Aspergillus fumigatus
2.5.1.80 physiological function the enzyme is involved in the biosynthesis of astechrome in Aspergillus fumigatus Aspergillus fumigatus