EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.1.127 | additional information | construction of Itpkb-/- mice transgenically expressing Itpkb in thymocytes, tese mutant mice have some peripheral T cells left. The mutant mice shows partial rescue of T cell lineage development through recombinant expression of HA-tagged isozyme Itpkb in thymocytes | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Ca2+ | the enzyme is highly activated by Ca2+/calmodulin | Mus musculus | |
2.7.1.127 | Mg2+ | required | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Mus musculus | B2RXC2 | gene Itpkb | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.127 | B-lymphocyte | - |
Mus musculus | - |
2.7.1.127 | mast cell | - |
Mus musculus | - |
2.7.1.127 | additional information | ubiquitous tissue expression of isozyme Itpkb, the Itpkb protein contributes mainly to the majority of the Ins(1,4,5)P3 3-kinase activity in resting T and B lymphocytes as well as in neutrophils and mast cells | Mus musculus | - |
2.7.1.127 | neutrophil | - |
Mus musculus | - |
2.7.1.127 | spleen | - |
Mus musculus | - |
2.7.1.127 | T-cell | - |
Mus musculus | - |
2.7.1.127 | T-lymphocyte | - |
Mus musculus | - |
2.7.1.127 | thymocyte | - |
Mus musculus | - |
2.7.1.127 | thymus | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.127 | inositol 1,4,5-trisphosphate 3-kinase B | - |
Mus musculus |
2.7.1.127 | Itpkb | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.127 | malfunction | mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase have a severe defect in thymocytes differentiation and thus lack peripheral T cells. Mutant T cells show an increased activated/memory phenotype as well as a decreased proliferative capacity and survival, Itpkb-deficient peripheral T cells have also an increased capacity to secrete cytokines upon stimulation | Mus musculus |
2.7.1.127 | physiological function | functional role of isozyme Itpkb in peripheral T cells, potential role for Itpkb in autoimmunity | Mus musculus |