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Literature summary extracted from

  • Muthu, P.; Chen, H.X.; Lutz, S.
    Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography (2014), ACS Chem. Biol., 9, 2326-2333.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.74 expressed in Escherichia coli BL21(DE3)pLysS cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.74 in complex with 5-methyldeoxycytidine and ADP, hanging drop vapor diffusion method Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.74 A100V/R104M/D133S the mutant shows exquisitely high activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 A100V/R104M/D133S/E196A the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 A100V/R104M/D133S/E196L inactive Homo sapiens
2.7.1.74 A100V/R104M/D133S/F96D inactive Homo sapiens
2.7.1.74 A100V/R104M/D133S/F96Y the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 A100V/R104M/D133S/W58E inactive Homo sapiens
2.7.1.74 A100V/R104M/D133S/W58V the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/A138I inactive Homo sapiens
2.7.1.74 R104M/D133N/L102Y the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/L191A the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/M85Y the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/P89F inactive Homo sapiens
2.7.1.74 R104M/D133N/V130T the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/V130T/L191A the mutant shows low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/V55E the mutant shows very low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/V55F the mutant shows very low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/V55F/V130T the mutant shows very low activity for D-deoxycytidine and D-thymidine Homo sapiens
2.7.1.74 R104M/D133N/V55F/V130T/L191A the mutant shows very low activity for D-deoxycytidine and D-thymidine Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens P27707
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.74 Ni-NTA agarose resin column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + deoxycytidine
-
Homo sapiens ADP + dCMP
-
?
2.7.1.74 ATP + thymidine
-
Homo sapiens ADP + L-dTMP
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 2'-deoxycytidine kinase
-
Homo sapiens
2.7.1.74 dCK
-
Homo sapiens