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Literature summary extracted from

  • Xiao, M.; Tang, Y.; Chen, W.W.; Wang, Y.L.; Yang, L.; Li, X.; Song, G.L.; Kuang, J.
    Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells (2016), Tumour Biol., 37, 2353-2363.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.31 NAD+ + protein L-arginine Mus musculus
-
 nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.31 Mus musculus Q60935
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.31 colon carcinoma cell
-
 Mus musculus
-
2.4.2.31 CT-26 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.31 NAD+ + protein L-arginine
-
 Mus musculus nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.31 arginine ADP-ribosyltransferase 1
-
 Mus musculus
2.4.2.31 ART1
-
 Mus musculus
2.4.2.31 mono-ADP-ribosyltransferase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.2.31 malfunction enzyme knockdown increases apoptosis of CT-26 cells transplant tumor. Furthermore, the activity of Akt and Erk cell signal pathways and expression of an apoptosis biomarker, betaIIItubulin, decrease when the enzyme is silenced Mus musculus