BRENDA - Enzyme Database show

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Zabka, T.S.; Singh, J.; Dhawan, P.; Liederer, B.M.; Oeh, J.; Kauss, M.A.; Xiao, Y.; Zak, M.; Lin, T.; McCray, B.; La, N.; Nguyen, T.; Beyer, J.; Farman, C.; Uppal, H.; Dragovich, P.S.; OBrien, T.; Sampath, D.; Misner, D.L.; Toxicol. Sci. 144, 163-172 (2015)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
APO866
formerly FK866
Homo sapiens
2.4.2.12
APO866
formerly FK866
Rattus norvegicus
2.4.2.12
GMX-1778
formerly CHS-828
Homo sapiens
2.4.2.12
GMX-1778
formerly CHS-828
Rattus norvegicus
2.4.2.12
GNE-617
-
Homo sapiens
2.4.2.12
GNE-618
-
Homo sapiens
2.4.2.12
GNE-643
-
Homo sapiens
2.4.2.12
GNE-875
-
Homo sapiens
2.4.2.12
N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
-
Homo sapiens
2.4.2.12
N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
-
Rattus norvegicus
2.4.2.12
N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide
-
Homo sapiens
2.4.2.12
N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide
-
Rattus norvegicus
2.4.2.12
N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide
-
Homo sapiens
2.4.2.12
N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Homo sapiens
P43490
-
-
2.4.2.12
Rattus norvegicus
Q80Z29
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
A-2780 cell
-
Homo sapiens
-
2.4.2.12
HCT-116 cell
-
Homo sapiens
-
2.4.2.12
HT-1080 cell
-
Homo sapiens
-
2.4.2.12
PC-3 cell
-
Homo sapiens
-
2.4.2.12
retinal pigment epithelium cell
-
Homo sapiens
-
2.4.2.12
retinal pigment epithelium cell
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
737279
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
737279
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
APO866
formerly FK866
Homo sapiens
2.4.2.12
APO866
formerly FK866
Rattus norvegicus
2.4.2.12
GMX-1778
formerly CHS-828
Homo sapiens
2.4.2.12
GMX-1778
formerly CHS-828
Rattus norvegicus
2.4.2.12
GNE-617
-
Homo sapiens
2.4.2.12
GNE-618
-
Homo sapiens
2.4.2.12
GNE-643
-
Homo sapiens
2.4.2.12
GNE-875
-
Homo sapiens
2.4.2.12
N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
-
Homo sapiens
2.4.2.12
N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
-
Rattus norvegicus
2.4.2.12
N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide
-
Homo sapiens
2.4.2.12
N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide
-
Rattus norvegicus
2.4.2.12
N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide
-
Homo sapiens
2.4.2.12
N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
A-2780 cell
-
Homo sapiens
-
2.4.2.12
HCT-116 cell
-
Homo sapiens
-
2.4.2.12
HT-1080 cell
-
Homo sapiens
-
2.4.2.12
PC-3 cell
-
Homo sapiens
-
2.4.2.12
retinal pigment epithelium cell
-
Homo sapiens
-
2.4.2.12
retinal pigment epithelium cell
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
737279
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
737279
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?