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Literature summary extracted from

  • Wilhelmus, M.M.; de Jager, M.; Smit, A.B.; van der Loo, R.J.; Drukarch, B.
    Catalytically active tissue transglutaminase colocalises with Abeta pathology in Alzheimers disease mouse models (2016), Sci. Rep., 6, 20569.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 Z-DON-Val-Pro-Leu-OMe irreversible inhibitor Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.13 [amyloid-beta]-L-glutamine + alkylamine Mus musculus
-
 [amyloid-beta]-N5-alkyl-L-glutamine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 [amyloid-beta]-L-glutamine + alkylamine
-
 Mus musculus [amyloid-beta]-N5-alkyl-L-glutamine + NH3
-
 ?
2.3.2.13 [T26 protein]-L-glutamine + 5-(biotinamido)-pentylamine
-
 Mus musculus [T26 protein]-N5-pentyl-L-glutamine + biotin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.13 tissue transglutaminase
-
 Mus musculus
2.3.2.13 tTG
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.2.13 physiological function the enzyme is associated with amyloid-beta deposits and lesion-associated astrocytes in Alzheimer's disease Mus musculus