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Literature summary extracted from

  • Zeqiraj, E.; Tang, X.; Hunter, R.; Garcia-Rocha, M.; Judd, A.; Deak, M.; Von Wilamowitz-Moellendorff, A.; Kurinov, I.; Guinovart, J.; Tyers, M.; Sakamoto, K.; Sicheri, F.
    Structural basis for the recruitment of glycogen synthase by glycogenin (2014), Proc. Natl. Acad. Sci. USA, 111, E2831-E2840.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.186 glycogen synthase-glycogenin enzyme complex, PDB ID 4QLB, GS-N interaction surface, overview Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.186 additional information construction of a truncated enzyme version CeGN34. The CeGNDELTAC mutant is defective for interaction with glycogen synthase CeGS Caenorhabditis elegans
2.4.1.186 Y194F site-directed mutagenesis, inactive mutant Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.186 Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.186 UDP-alpha-D-glucose + glycogenin self-glucosylation of the glycosyltransferase glycogenin Caenorhabditis elegans UDP + alpha-D-glucosylglycogenin
-
?

Subunits

EC Number Subunits Comment Organism
2.4.1.186 More glycogenin is a member of the GT8 family of glycosyltransferases with a GT-A architecture containing an N-terminal catalytic domain with a single Rossmann fold that operates as an obligate dimer. The core catalytic domain is followed by a C-terminal extension of variable length and undefined structure. Oligomerization of glycogenin and glycogen synthase from Caenorhabditis elegans enhances binding through an avidity effect Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
2.4.1.186 CeGN
-
Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.4.1.186 evolution glycogenin is a member of the GT8 family of glycosyltransferases with a GT-A architecture Caenorhabditis elegans
2.4.1.186 additional information interaction and binding of wild-type full-length enzyme and truncated mutant CeGN34 to glycogen synthase, the CeGS-CeGN34 interaction is required for glycogen formation, overview Caenorhabditis elegans