Literature summary extracted from
Zeqiraj, E.; Tang, X.; Hunter, R.; Garcia-Rocha, M.; Judd, A.; Deak, M.; Von Wilamowitz-Moellendorff, A.; Kurinov, I.; Guinovart, J.; Tyers, M.; Sakamoto, K.; Sicheri, F.
Structural basis for the recruitment of glycogen synthase by glycogenin (2014), Proc. Natl. Acad. Sci. USA, 111, E2831-E2840.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
2.4.1.186 |
glycogen synthase-glycogenin enzyme complex, PDB ID 4QLB, GS-N interaction surface, overview |
Caenorhabditis elegans |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
2.4.1.186 |
additional information |
construction of a truncated enzyme version CeGN34. The CeGNDELTAC mutant is defective for interaction with glycogen synthase CeGS |
Caenorhabditis elegans |
2.4.1.186 |
Y194F |
site-directed mutagenesis, inactive mutant |
Caenorhabditis elegans |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.4.1.186 |
Caenorhabditis elegans |
- |
- |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.4.1.186 |
UDP-alpha-D-glucose + glycogenin |
self-glucosylation of the glycosyltransferase glycogenin |
Caenorhabditis elegans |
UDP + alpha-D-glucosylglycogenin |
- |
? |
|
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
2.4.1.186 |
More |
glycogenin is a member of the GT8 family of glycosyltransferases with a GT-A architecture containing an N-terminal catalytic domain with a single Rossmann fold that operates as an obligate dimer. The core catalytic domain is followed by a C-terminal extension of variable length and undefined structure. Oligomerization of glycogenin and glycogen synthase from Caenorhabditis elegans enhances binding through an avidity effect |
Caenorhabditis elegans |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.4.1.186 |
CeGN |
- |
Caenorhabditis elegans |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.4.1.186 |
evolution |
glycogenin is a member of the GT8 family of glycosyltransferases with a GT-A architecture |
Caenorhabditis elegans |
2.4.1.186 |
additional information |
interaction and binding of wild-type full-length enzyme and truncated mutant CeGN34 to glycogen synthase, the CeGS-CeGN34 interaction is required for glycogen formation, overview |
Caenorhabditis elegans |