Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.
    Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin (2014), PLoS ONE, 9, e113498.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.50 expressed in MEF cells Homo sapiens
2.4.1.66 expressed in MEF cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.50 UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine Homo sapiens
-
 UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
 ?
2.4.1.66 UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] Homo sapiens
-
 UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.50 Homo sapiens
-
-
-
2.4.1.66 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.50 additional information LH3 is the only enzyme capable of glucosylating the galactosylhydroxylysine residues in proteins with a collagenous domain Homo sapiens ?
-
 ?
2.4.1.50 UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
-
 Homo sapiens UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
 ?
2.4.1.66 UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen]
-
 Homo sapiens UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.50 LH3
-
 Homo sapiens
2.4.1.50 lysyl hydroxylase 3 a multifunctional protein with lysyl hydroxylase, collagen galactosyltransferase and glucosyltransferase activities Homo sapiens
2.4.1.66 LH3
-
 Homo sapiens
2.4.1.66 lysyl hydroxylase 3 a multifunctional protein with lysyl hydroxylase, collagen galactosyltransferase and glucosyltransferase activities Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.1.50 metabolism the enzyme is commonly involved in biosynthesis of collagenous proteins Homo sapiens
2.4.1.66 metabolism the enzyme is commonly involved in biosynthesis of collagenous proteins Homo sapiens