Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Watt, S.A.; Dayal, J.H.; Wright, S.; Riddle, M.; Pourreyron, C.; McMillan, J.R.; Kimble, R.M.; Prisco, M.; Gartner, U.; Warbrick, E.; McLean, W.H.; Leigh, I.M.; McGrath, J.A.; Salas-Alanis, J.C.; Tolar, J.; South, A.P.
    Lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa (2015), PLoS ONE, 10, e0137639.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.66 80000
-
 2 * 80000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.66 UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] Homo sapiens
-
 UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
-
 ?
2.4.1.66 UDP-glucose + type VII collagen Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.66 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.66 keratinocyte
-
 Homo sapiens
-
2.4.1.66 skin epidermal basement membrane Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.66 UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen]
-
 Homo sapiens UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
-
 ?
2.4.1.66 UDP-glucose + type VII collagen
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.66 ? 2 * 80000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.66 LH3
-
 Homo sapiens
2.4.1.66 lysyl hydroxylase 3
-
 Homo sapiens
2.4.1.66 PLOD3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.66 Homo sapiens enzyme levels are reduced in patients with recessive dystrophic epidermolysis bullosa down
2.4.1.66 Homo sapiens exogenous type VII collagen do not alter enzyme expression in cultured recessive dystrophic epidermolysis bullosa keratinocytes additional information