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Literature summary extracted from

  • Lu, L.; Zhou, J.; Shi, J.; Peng, X.J.; Qi, X.X.; Wang, Y.; Li, F.Y.; Zhou, F.Y.; Liu, L.; Liu, Z.Q.
    Drug-metabolizing activity, protein and gene expression of UDP-glucuronosyltransferases are significantly altered in hepatocellular carcinoma patients (2015), PLoS ONE, 10, e0127524.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 gene UGT1A1, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens
2.4.1.17 gene UGT1A4, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens
2.4.1.17 gene UGT1A9, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens
2.4.1.17 gene UGT2B7, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information Km values of isozymes using different specific substrates at different concentrations with healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin Homo sapiens i.e. SN-38, an active metabolite of irinotecan UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + genistein Homo sapiens
-
 UDP + genistein beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol Homo sapiens
-
 UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + tamoxifen Homo sapiens
-
 UDP + tamoxifen N-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + zidovudine Homo sapiens
-
 UDP + zidovudine beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656 UGT1A9; UGT1A9
-
2.4.1.17 Homo sapiens P16662 UGT2B7; UGT2B7
-
2.4.1.17 Homo sapiens P22309 UGT1A1; UGT1A1
-
2.4.1.17 Homo sapiens P22310 UGT1A4; UGT1A4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 hepatocellular carcinoma cell
-
 Homo sapiens
-
2.4.1.17 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin i.e. SN-38, an active metabolite of irinotecan Homo sapiens UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + genistein
-
 Homo sapiens UDP + genistein beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Homo sapiens UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + tamoxifen
-
 Homo sapiens UDP + tamoxifen N-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + zidovudine
-
 Homo sapiens UDP + zidovudine beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT1A1
-
 Homo sapiens
2.4.1.17 UGT1A4
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.1.17 malfunction the complete absence of UGT1A1 activity results in Crigler-Najjar's syndrome type I, brain damage, and even death Homo sapiens
2.4.1.17 physiological function metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues Homo sapiens