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Literature summary extracted from

  • Yao, M.; Cai, M.; Yao, D.; Xu, X.; Yang, R.; Li, Y.; Zhang, Y.; Kido, H.; Yao, D.
    Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts (2015), PLoS ONE, 10, e0119936.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.21 F352C/V368I the mutant shows thermal instability, reduced residual enzyme activities and a short half-life compared to the wild type enzyme Homo sapiens
2.3.1.21 V368I the mutant shows thermal instability, reduced residual enzyme activities and a short half-life compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens P23786
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 fibroblast
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 0.00018
-
 mutant enzyme F352C/V368I, at 30°C, pH not specified in the publication Homo sapiens
2.3.1.21 0.00027
-
 mutant enzyme V368I, at 30°C, pH not specified in the publication Homo sapiens
2.3.1.21 0.00028
-
 wild type enzyme, at 30°C, pH not specified in the publication Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.21 homotetramer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyltransferase II
-
 Homo sapiens
2.3.1.21 CPT II
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.21 malfunction enzyme deficiency leads to a significant decrease in fatty acid beta-oxidation and adenosine triphosphate generation, combined with a reduced mitochondrial membrane potential, resulting in cellular apoptosis Homo sapiens