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Literature summary extracted from

  • Seo, J.H.; Kim, M.O.; Han, A.R.; Kwon, E.B.; Kang, M.J.; Cho, S.; Moon, D.O.; Noh, J.R.; Lee, C.H.; Kim, Y.S.; Lee, H.S.
    Oleanane-type triterpenoids of Aceriphyllum rossii and their diacylglycerol acyltransferase-inhibitory activity (2015), Planta Med., 81, 228-234.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.20 3-oxoolean-12-en-27-oic acid the compound exhibits strong inhibition efficacy towards diacylglycerol acyltransferases 1 and 2, and acts competitively against oleoyl-CoA in vitro Homo sapiens
2.3.1.20 3alpha-hydroxyolean-12-en-27-oic acid
-
 Homo sapiens
2.3.1.20 3beta-hydroxyolean-12-en-27-oic acid
-
 Homo sapiens
2.3.1.20 aceriphyllic acid A the compound exhibits strong inhibition efficacy towards diacylglycerol acyltransferases 1 and 2, and acts competitively against oleoyl-CoA in vitro Homo sapiens
2.3.1.20 gypsogenic acid
-
 Homo sapiens
2.3.1.20 oleanolic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.20 acyl-CoA + 1,2-diacyl-sn-glycerol Homo sapiens
-
 CoA + triacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.20 HuTu-80 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 acyl-CoA + 1,2-diacyl-sn-glycerol
-
 Homo sapiens CoA + triacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 DGAT1 isoform Homo sapiens
2.3.1.20 DGAT2 isoform Homo sapiens
2.3.1.20 diacylglycerol acyltransferase
-
 Homo sapiens