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Literature summary extracted from

  • Ning, J.; Moghe, G.D.; Leong, B.; Kim, J.; Ofner, I.; Wang, Z.; Adams, C.; Jones, A.D.; Zamir, D.; Last, R.L.
    A feedback-insensitive isopropylmalate synthase affects acylsugar composition in cultivated and wild tomato (2015), Plant Physiol., 169, 1821-1835.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.3.13 expressed in Escherichia coli BL21 Rosetta cells Solanum lycopersicum
2.3.3.13 expressed in Escherichia coli BL21 Rosetta cells Solanum pennellii

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.13 L-leucine
-
Solanum lycopersicum
2.3.3.13 L-leucine
-
Solanum pennellii
2.3.3.13 additional information isoform IPMS3 is not subject to L-leucine feedback inhibition; isoform IPMS3 is not subject to L-leucine feedback inhibition Solanum lycopersicum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.3.13 0.143
-
2-oxoisovalerate isoform IPMS1, pH and temperature not specified in the publication Solanum lycopersicum
2.3.3.13 0.215
-
2-oxoisovalerate isoform IPMS3, pH and temperature not specified in the publication Solanum lycopersicum
2.3.3.13 0.734
-
4-methylthio-2-oxobutyrate isoform IPMS3, pH and temperature not specified in the publication Solanum lycopersicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.13 acetyl-CoA + 3-methyl-2-oxobutanoate + H2O Solanum lycopersicum
-
(2S)-2-isopropylmalate + CoA
-
?
2.3.3.13 acetyl-CoA + 3-methyl-2-oxobutanoate + H2O Solanum pennellii
-
(2S)-2-isopropylmalate + CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.13 Solanum lycopersicum K4C627 isoform IPMS1; M82
-
2.3.3.13 Solanum lycopersicum K4C627 isoform IPMS2; M82
-
2.3.3.13 Solanum lycopersicum K4CJ56 isoform IPMS3; M82
-
2.3.3.13 Solanum pennellii A0A0G2T6D7 isoform IPMS3; LA071
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.3.13 Ni-NTA column chromatography Solanum lycopersicum
2.3.3.13 Ni-NTA column chromatography Solanum pennellii

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.13 stem
-
Solanum lycopersicum
-
2.3.3.13 stem
-
Solanum pennellii
-
2.3.3.13 trichome
-
Solanum lycopersicum
-
2.3.3.13 trichome
-
Solanum pennellii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.13 acetyl-CoA + 2-oxoisovalerate + H2O
-
Solanum lycopersicum ?
-
?
2.3.3.13 acetyl-CoA + 2-oxoisovalerate + H2O
-
Solanum pennellii ?
-
?
2.3.3.13 acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
-
Solanum lycopersicum (2S)-2-isopropylmalate + CoA
-
?
2.3.3.13 acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
-
Solanum pennellii (2S)-2-isopropylmalate + CoA
-
?
2.3.3.13 acetyl-CoA + 4-methylthio-2-oxobutyrate + H2O
-
Solanum lycopersicum ?
-
?
2.3.3.13 acetyl-CoA + 4-methylthio-2-oxobutyrate + H2O
-
Solanum pennellii ?
-
?
2.3.3.13 additional information isoform IPMS3 shows no activity with 4-methylthio-2-oxobutyrate or 2-oxoisovalerate Solanum pennellii ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.13 IPMS1 isoform Solanum lycopersicum
2.3.3.13 IPMS2 isoform Solanum lycopersicum
2.3.3.13 IPMS3 isoform Solanum pennellii
2.3.3.13 IPMS3 isoform Solanum lycopersicum
2.3.3.13 isopropylmalate synthase
-
Solanum lycopersicum
2.3.3.13 isopropylmalate synthase
-
Solanum pennellii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.3.13 0.12
-
4-methylthio-2-oxobutyrate isoform IPMS3, pH and temperature not specified in the publication Solanum lycopersicum
2.3.3.13 0.49
-
2-oxoisovalerate isoform IPMS3, pH and temperature not specified in the publication Solanum lycopersicum
2.3.3.13 1.08
-
2-oxoisovalerate isoform IPMS1, pH and temperature not specified in the publication Solanum lycopersicum

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.3.13 0.16
-
4-methylthio-2-oxobutyrate isoform IPMS3, pH and temperature not specified in the publication Solanum lycopersicum
2.3.3.13 2.3
-
2-oxoisovalerate isoform IPMS3, pH and temperature not specified in the publication Solanum lycopersicum
2.3.3.13 7.5
-
2-oxoisovalerate isoform IPMS1, pH and temperature not specified in the publication Solanum lycopersicum