Literature summary extracted from

Knights, K.M.; Jones, M.E.
Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs (1992), Biochem. Pharmacol., 43, 1465-1471.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.2.1.3	Ketoprofen	non-competitive inhibition of the high affinity isoform	Rattus norvegicus
6.2.1.3	naproxen	non-competitive inhibition of the high affinity isoform	Rattus norvegicus
6.2.1.3	R-Fenoprofen	mixed inhibition of the high affinity isoform	Rattus norvegicus
6.2.1.3	R-Ibuprofen	mixed inhibition of the high affinity isoform	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
6.2.1.3	microsome	-	Rattus norvegicus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.2.1.3	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.2.1.3	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.2.1.3	ATP + palmitate + CoA	-	Rattus norvegicus	AMP + diphosphate + palmitoyl-CoA	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)