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Literature summary extracted from

  • Chen, X.L.; Shi, T.; Yang, J.; Shi, W.; Gao, X.; Chen, D.; Xu, X.; Xu, J.R.; Talbot, N.J.; Peng, Y.L.
    N-glycosylation of effector proteins by an alpha-1,3-mannosyltransferase is required for the rice blast fungus to evade host innate immunity (2014), Plant Cell, 26, 1360-1376.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.258 Pyricularia oryzae M1RXP4
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.258 dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
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 Pyricularia oryzae D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
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2.4.1.258 additional information Alg3-mediated N-glycosylation of the effector, Secreted LysM Protein1 (Slp1), is essential for its activity. Slp1 has three N-glycosylation sites and simultaneous Alg3-mediated N-glycosylation of each site is required to maintain protein stability and the chitin binding activity of Slp1 Pyricularia oryzae ?
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General Information

EC Number General Information Comment Organism
2.4.1.258 physiological function deletion of Alg3 results in the arrest of secondary infection hyphae and a significant reduction in virulence. Alg3 deletion mutants induce massive production of reactive oxygen species in host cells. Alg3-mediated N-glycosylation of the effector, Secreted LysM Protein1 (Slp1), is essential for its activity. Alg3 deletion mutants accumulate reactive oxygen species in a similar manner to Slp1 deletion mutants, which is a key factor responsible for arresting infection hyphae of the mutants Pyricularia oryzae