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Literature summary extracted from

  • Paulose, B.; Chhikara, S.; Coomey, J.; Jung, H.I.; Vatamaniuk, O.; Dhankher, O.P.
    A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis (2013), Plant Cell, 25, 4580-4595.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.2.9 expressed in Saccharomyces cerevisiae strain HD9 Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.9 Arabidopsis thaliana
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.9 flower
-
 Arabidopsis thaliana
-
4.3.2.9 meristem
-
 Arabidopsis thaliana
-
4.3.2.9 root
-
 Arabidopsis thaliana
-
4.3.2.9 sepal
-
 Arabidopsis thaliana
-
4.3.2.9 vascular tissue
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.9 5-L-glutamyl-L-alanine low activity compared to glutathione Arabidopsis thaliana 5-oxoproline + L-alanine
-
 ?
4.3.2.9 glutathione
-
 Arabidopsis thaliana 5-oxoproline + L-Cys-Gly
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.9 gamma-glutamyl cyclotransferase
-
 Arabidopsis thaliana
4.3.2.9 GGCT2;1 isoform Arabidopsis thaliana

Expression

EC Number Organism Comment Expression
4.3.2.9 Arabidopsis thaliana the enzyme is upregulated after 0.025 mM arsenite treatment up

General Information

EC Number General Information Comment Organism
4.3.2.9 metabolism isoform GGCT2;1 participates in the cellular response to arsenic via glutathione degradation. The enzyme ensures sufficient glutathione turnover during abiotic stress by recycling L-Glu. Enzyme overexpression provides enhanced arsenite tolerance in Arabidopsis and decreases nitrogen requirement under arsenite toxicity Arabidopsis thaliana