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Literature summary extracted from

  • Liao, P.; Wang, H.; Hemmerlin, A.; Nagegowda, D.A.; Bach, T.J.; Wang, M.; Chye, M.L.
    Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway (2014), Plant Cell Rep., 33, 1005-1022.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.10 F-244
-
 Arabidopsis thaliana
2.3.3.10 F-244
-
 Brassica juncea
2.3.3.10 F-244
-
 Camptotheca acuminata
2.3.3.10 F-244
-
 Catharanthus roseus
2.3.3.10 F-244
-
 Gallus gallus
2.3.3.10 F-244
-
 Hevea brasiliensis
2.3.3.10 F-244
-
 Homo sapiens
2.3.3.10 F-244
-
 Melampsora larici-populina
2.3.3.10 F-244
-
 Mesocricetus auratus
2.3.3.10 F-244
-
 Pinus sylvestris
2.3.3.10 F-244
-
 Populus trichocarpa x Populus deltoides
2.3.3.10 F-244
-
 Rattus norvegicus
2.3.3.10 F-244
-
 Salvia miltiorrhiza
2.3.3.10 F-244
-
 Solanum lycopersicum
2.3.3.10 F-244
-
 Sus scrofa
2.3.3.10 F-244
-
 Taxus x media

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.3.10 cytosol
-
 Mesocricetus auratus 5829
-
2.3.3.10 cytosol
-
 Catharanthus roseus 5829
-
2.3.3.10 cytosol
-
 Arabidopsis thaliana 5829
-
2.3.3.10 cytosol
-
 Gallus gallus 5829
-
2.3.3.10 cytosol
-
 Pinus sylvestris 5829
-
2.3.3.10 cytosol
-
 Rattus norvegicus 5829
-
2.3.3.10 cytosol
-
 Sus scrofa 5829
-
2.3.3.10 cytosol
-
 Populus trichocarpa x Populus deltoides 5829
-
2.3.3.10 cytosol
-
 Brassica juncea 5829
-
2.3.3.10 cytosol
-
 Taxus x media 5829
-
2.3.3.10 cytosol
-
 Solanum lycopersicum 5829
-
2.3.3.10 cytosol
-
 Salvia miltiorrhiza 5829
-
2.3.3.10 cytosol
-
 Camptotheca acuminata 5829
-
2.3.3.10 cytosol
-
 Hevea brasiliensis 5829
-
2.3.3.10 cytosol
-
 Homo sapiens 5829
-
2.3.3.10 cytosol
-
 Melampsora larici-populina 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.3.10 51280
-
 x * 51280, calculated from amino acid sequence Hevea brasiliensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Mesocricetus auratus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Catharanthus roseus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Arabidopsis thaliana
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Gallus gallus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Pinus sylvestris
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Rattus norvegicus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Sus scrofa
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Populus trichocarpa x Populus deltoides
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Brassica juncea
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Taxus x media
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Solanum lycopersicum
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Salvia miltiorrhiza
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Camptotheca acuminata
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Hevea brasiliensis
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Homo sapiens
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Melampsora larici-populina
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Arabidopsis thaliana P54873
-
-
2.3.3.10 Brassica juncea Q9M6U3
-
-
2.3.3.10 Camptotheca acuminata B3GDB1
-
-
2.3.3.10 Catharanthus roseus
-
-
-
2.3.3.10 Gallus gallus P23228
-
-
2.3.3.10 Hevea brasiliensis Q94ET0
-
-
2.3.3.10 Homo sapiens A0A024R059
-
-
2.3.3.10 Melampsora larici-populina
-
-
-
2.3.3.10 Mesocricetus auratus
-
-
-
2.3.3.10 Pinus sylvestris P93773
-
-
2.3.3.10 Populus trichocarpa x Populus deltoides
-
-
-
2.3.3.10 Rattus norvegicus P17425
-
-
2.3.3.10 Salvia miltiorrhiza D2DS62
-
-
2.3.3.10 Solanum lycopersicum A9LRT6
-
-
2.3.3.10 Sus scrofa O02734
-
-
2.3.3.10 Taxus x media Q693N8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.10 latex
-
 Hevea brasiliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Mesocricetus auratus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Catharanthus roseus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Arabidopsis thaliana (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Pinus sylvestris (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Sus scrofa (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Populus trichocarpa x Populus deltoides (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Brassica juncea (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Taxus x media (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Solanum lycopersicum (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Salvia miltiorrhiza (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Camptotheca acuminata (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Hevea brasiliensis (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Homo sapiens (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Melampsora larici-populina (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.3.10 ? x * 51280, calculated from amino acid sequence Hevea brasiliensis

Synonyms

EC Number Synonyms Comment Organism
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Mesocricetus auratus
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Catharanthus roseus
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Arabidopsis thaliana
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Gallus gallus
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Pinus sylvestris
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Rattus norvegicus
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Sus scrofa
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Populus trichocarpa x Populus deltoides
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Brassica juncea
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Taxus x media
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Solanum lycopersicum
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Salvia miltiorrhiza
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Camptotheca acuminata
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Hevea brasiliensis
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Homo sapiens
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Melampsora larici-populina
2.3.3.10 HMGS
-
 Mesocricetus auratus
2.3.3.10 HMGS
-
 Catharanthus roseus
2.3.3.10 HMGS
-
 Arabidopsis thaliana
2.3.3.10 HMGS
-
 Gallus gallus
2.3.3.10 HMGS
-
 Pinus sylvestris
2.3.3.10 HMGS
-
 Rattus norvegicus
2.3.3.10 HMGS
-
 Sus scrofa
2.3.3.10 HMGS
-
 Populus trichocarpa x Populus deltoides
2.3.3.10 HMGS
-
 Brassica juncea
2.3.3.10 HMGS
-
 Taxus x media
2.3.3.10 HMGS
-
 Solanum lycopersicum
2.3.3.10 HMGS
-
 Salvia miltiorrhiza
2.3.3.10 HMGS
-
 Camptotheca acuminata
2.3.3.10 HMGS
-
 Hevea brasiliensis
2.3.3.10 HMGS
-
 Homo sapiens
2.3.3.10 HMGS
-
 Melampsora larici-populina