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Literature summary extracted from

  • Duval, R.; Xu, X.; Bui, L.C.; Mathieu, C.; Petit, E.; Cariou, K.; Dodd, R.H.; Dupret, J.M.; Rodrigues-Lima, F.
    Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens (2016), Oncotarget, 7, 8688-8699.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 Benzyl isothiocyanate
-
 Homo sapiens
2.3.1.5 additional information not inhibited by N-methylphenethylamine. GSH or dithiothreitol are unable to reactivate significantly inhibited isoform NAT1 Homo sapiens
2.3.1.5 phenethyl isothiocyanate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.5 His-select nickel resin column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 4-nitrophenyl acetate + 4-aminobenzoic acid
-
 Homo sapiens 4-nitrophenol + N-acetyl-4-aminobenzoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 NAT1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.5 0.007
-
 at pH 7.5 and 37°C Homo sapiens Benzyl isothiocyanate
2.3.1.5 0.015
-
 at pH 7.5 and 37°C Homo sapiens phenethyl isothiocyanate