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Literature summary extracted from

  • Goswami, M.; Chen, G.; Chakravarthi, B.; Pathi, S.; Anand, S.; Carskadon, S.; Giordano, T.; Chinnaiyan, A.; Thomas, D.; Palanisamy, N.; Beer, D.; Varambally, S.
    Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer (2015), Oncotarget, 6, 23445-23461.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.14 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate Homo sapiens
-
 L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.14 Homo sapiens Q06203
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.14 A-549 cell
-
 Homo sapiens
-
2.4.2.14 lung adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.14 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate
-
 Homo sapiens L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.14 phosphoribosyl amidotransferase
-
 Homo sapiens
2.4.2.14 PPAT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.2.14 Homo sapiens increased enzyme expression correlates with aggressive lung cancer. L-glutamine induces enzyme expression up

General Information

EC Number General Information Comment Organism
2.4.2.14 physiological function the enzyme is critical for lung cancer cell proliferation and invasion Homo sapiens